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公开(公告)号：US5622745A
公开(公告)日：1997-04-22
申请号：US374449
申请日：1995-01-18
CPC分类号： B32B15/08 , A61J1/1425 , A61J1/18 , B65D51/002 , A61J1/1468 , Y10T428/1355
摘要： A method is provided for reducing particle formation during manufacture of shell caps for containers such as pharmaceutical containers. The method entails providing a solid polymeric coating on substantially all surfaces of the shell caps to form coated shell caps before permitting the coated shell caps to contact each other or other objects. A pharmaceutical container which employs the shell caps also is provided. The container comprises a vial for storing medicinal compositions therein and a shell cap for sealing the vial. The shell cap includes a hollow metallic preform and a solid polymeric coating which substantially completely encapsulates the preform.
摘要翻译： 提供了一种用于在用于诸如药物容器的容器的壳盖的制造期间减少颗粒形成的方法。 该方法需要在壳盖的基本上所有表面上提供固体聚合物涂层，以在允许涂覆的壳盖彼此接触或其它物体之前形成涂覆的外壳盖。 还提供了采用壳帽的药物容器。 容器包括用于储存药物组合物的小瓶和用于密封小瓶的壳盖。 壳盖包括中空金属预制件和基本上完全包封预成型件的固体聚合物涂层。
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2.发明授权
公开(公告)号：US5794804A
公开(公告)日：1998-08-18
申请号：US828869
申请日：1997-03-31
CPC分类号： B32B15/08 , A61J1/1425 , A61J1/18 , B65D51/002 , A61J1/1468 , Y10T428/1355
摘要： A method is provided for reducing particle formation during manufacture of shell caps for containers such as pharmaceutical containers. The method entails providing a solid polymeric coating on substantially all surfaces of the shell caps to form coated shell caps before permitting the coated shell caps to contact each other or other objects. A pharmaceutical container which employs the shell caps also is provided. The container comprises a vial for storing medicinal compositions therein and a shell cap for sealing the vial. The shell cap includes a hollow metallic preform and a solid polymeric coating which substantially completely encapsulates the preform.
摘要翻译： 提供了一种用于在用于诸如药物容器的容器的壳盖的制造期间减少颗粒形成的方法。 该方法需要在壳盖的基本上所有表面上提供固体聚合物涂层，以在允许涂覆的壳盖彼此接触或其它物体之前形成涂覆的外壳盖。 还提供了采用壳帽的药物容器。 容器包括用于储存药物组合物的小瓶和用于密封小瓶的壳盖。 壳盖包括中空金属预制件和基本上完全包封预成型件的固体聚合物涂层。
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公开(公告)号：US4204605A
公开(公告)日：1980-05-27
申请号：US940607
申请日：1978-09-08
申请人： Jacob Ravn , William A. Conard
发明人： Jacob Ravn , William A. Conard
CPC分类号： B65D41/14 , B65D39/0029 , B65D39/16 , B65D51/18 , B65D2251/0015 , B65D2251/0075
摘要： A container-closure assembly. The container has a discharge opening, a locking flange of generally circular opening with a frusto conical side face diverging downwardly from the axial end face of the opening. A shaping surface is formed below the locking flange of non-circular cross section and has a maximum cross section less than the cross section of the locking flange and at least one cam member extends axially downwardly from the locking flange. The cap of the assembly has a top and a peripheral skirt portion engaging under the locking flange and extending at least to the juncture of the locking flange and shaping surface. The cap is of a deformable material whereby the skirt is shaped to a generally circular shape by the cam member upon relative rotation of the cap and container.
摘要翻译： 容器封闭组件。 容器具有排出口，大致圆形的开口的锁定凸缘，具有从开口的轴向端面向下扩散的截头圆锥形侧面。 成形表面形成在非圆形横截面的锁定凸缘的下方，并且具有小于锁定凸缘的横截面的最大横截面，并且至少一个凸轮构件从锁定凸缘轴向向下延伸。 组件的盖具有接合在锁定凸缘下方的顶部和周边裙部，并且至少延伸到锁定凸缘和成形表面的接合处。 帽是可变形的材料，由此在盖和容器的相对旋转时，裙部通过凸轮构件成形为大致圆形形状。
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公开(公告)号：US5114030A
公开(公告)日：1992-05-19
申请号：US574744
申请日：1990-08-30
申请人： William A. Conard
发明人： William A. Conard
CPC分类号： B65D51/002 , A61J1/1406 , A61J1/1425 , A61J1/1475 , A61J1/18 , A61J1/1468 , B65D2101/0023 , Y10S215/03
摘要： A container cap, comprising a cap body having an annular shoulder with an inner and outer terminal edge. The shoulder has a skirt depending from the outer terminal edge of the shoulder and an upper cylinder is attached to the annular shoulder at its inner terminal edge. The cylinder extends upward, terminating in an annular flared lip and the upper cylinder is attached to the shoulder by an annular scoring ring.
摘要翻译： 一种容器盖，包括具有带有内端和外端边缘的环形肩部的盖体。 肩部具有从肩部的外部末端边缘延伸的裙部，并且上部圆筒在其内部末端边缘附接到环形肩部。 气缸向上延伸，终止于环形喇叭形的唇部，上部气缸通过环形刻痕环连接到肩部。
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公开(公告)号：US4384653A
公开(公告)日：1983-05-24
申请号：US320578
申请日：1981-11-12
CPC分类号： B65D41/62 , A61J1/1425 , B65D39/16 , B65D41/16 , B65D51/243 , A61J1/1468
摘要： A tip-off cap and closure for a container, for closure thereof, and sealing of the contents therein. The cap includes a narrow elongated exterior top portion, a peripherally enlarged open bottom skirt at the bottom thereof, and a container closure for an access opening, operatively disposed within the skirt and operatively integrated therewith. The integrated cap and closure are conjointly removable from the container, to open the container for access to the liquid therein, by application of a lateral tilting force against the narrow, elongated cap exterior at a position thereof remote from connection of the cap to the container. Removal of the integrated cap and closure seal means from the container is normally effected without breakage of the material forming the container. The cap and closure act as a unit assembly when being removed. The construction is designed to generally assimilate currently known and used glass ampules for medicaments, in configuration and use, and to have a similar opening procedure thereto.
摘要翻译： 用于容器的顶盖和封盖，用于封闭盖子，并将内容物密封在其中。 盖子包括窄的细长的外部顶部部分，在其底部的外围扩大的开放的底部裙部，以及用于进入开口的容器封闭件，可操作地设置在裙部内并与之可操作地一体化。 集成的盖和封闭件可从容器中组合地移除，以通过在远离盖子与容器的连接的位置处对狭窄的细长的盖子外部施加横向倾斜力来打开容器以进入其中的液体 。 整体式盖和封闭式密封装置通常从容器中移除，而不破坏形成容器的材料。 拆卸时，盖和封盖作为单元组件。 该结构被设计成通常吸收当前已知和用过的用于药物的配置和使用的玻璃安瓿，并且具有类似的开启程序。
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公开(公告)号：US5433330A
公开(公告)日：1995-07-18
申请号：US312004
申请日：1994-09-23
申请人： Thomas Yatsko , Jerome D. Olivas , Edward F. Vander Bush , William A. Conard , Steven C. Jepson , Thomas E. Dudar
发明人： Thomas Yatsko , Jerome D. Olivas , Edward F. Vander Bush , William A. Conard , Steven C. Jepson , Thomas E. Dudar
IPC分类号： B65D51/18 , A61J1/00 , A61J1/05 , A61J1/14 , A61J1/20 , B65D51/00 , B65D51/22 , B65D39/00 , B65D41/20
CPC分类号： B65D51/222 , A61J1/1406 , A61J1/2096 , B65D51/002 , A61J1/201 , B65D2251/0015 , B65D2251/0056 , B65D2251/009 , Y10S215/03
摘要： Disclosed is a stopper for use with containers to provide needleless access to the container with a cannula having a blunt penetrating tip. Also disclosed is a system comprising the stopper, container and cannula. The stopper includes a disc having an upper face and a lower face, and a plug extending from the disc into the container. Also included is a diaphragm, defined by a target region in the upper face and a cross channel in the disc for controlling the force needed to penetrate the stopper with the cannula. The plug includes a first inward surface for guiding the cannula and a second inward surface for engaging the cannula to minimize wetting of the outside of the cannula. In a preferred embodiment, the first surface extends down from the cross channel on the lower side of the disc, radially outwardly to a maximum diameter and the second inwardly facing surface extends down from the first surface radially inwardly to a minimum diameter to form the cannula seal. Also shown is a centrally located piercing point positioned to pre-slit the diaphragm. An overcap may be provided to alternatively have an axially aligned boss and bore positioned to pre-slit the diaphragm. In another embodiment, the invention includes an annular pre-slit disc formed of self sealing material and positioned to reduce spray back when inserting or removing the cannula.
摘要翻译： 公开了一种用于与容器一起使用具有钝的穿透尖端的套管来无菌地进入容器的塞子。 还公开了一种包括塞子，容器和套管的系统。 止动器包括具有上表面和下表面的盘，以及从盘延伸到容器中的塞子。 还包括由上表面中的目标区域和盘中的横向通道限定的隔膜，用于控制用套管穿透塞子所需的力。 塞子包括用于引导套管的第一向内表面和用于接合套管的第二向内表面以最小化插管外部的润湿。 在优选实施例中，第一表面从盘的下侧的交叉通道向下延伸，径向向外延伸到最大直径，并且第二向内表面从第一表面径向向内延伸至最小直径以形成插管 密封。 还示出了定位成预先切割隔膜的位于中心的穿刺点。 可以提供顶盖以备选地具有轴向对齐的凸台和孔，以便预先切割隔膜。 在另一个实施例中，本发明包括由自密封材料形成并定位成在插入或移除插管时减少喷雾的环形预切割盘。
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公开(公告)号：US5080245A
公开(公告)日：1992-01-14
申请号：US497550
申请日：1990-03-22
申请人： William A. Conard
发明人： William A. Conard
IPC分类号： B65D51/00
CPC分类号： B65D51/002
摘要： A closure device for use with a container, comprising cap means with a pull tab and scoring to remove the cap, the scoring including stepped scoring on both sides of the cap with each scoring having a frangible interruption proximate the top radial edge of the cap.
摘要翻译： 一种与容器一起使用的封闭装置，包括具有拉片和刻划以除去盖子的帽装置，所述刻痕包括在盖的两侧上的阶梯式刻痕，每个刻痕在盖的顶部径向边缘处具有易碎的中断。
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公开(公告)号：US4830208A
公开(公告)日：1989-05-16
申请号：US145274
申请日：1988-01-19
IPC分类号： B65D55/08
CPC分类号： B65D55/0845 , Y10T292/207
摘要： A tamper-proof ring for securing a closure over the open end of a container. The closure and container has a projection engageable by the ring which comprises an annular member which before application to a container-closure assembly has a generally cylindrical section of a diameter slightly greater than the greatest transverse dimension of the container. The closure projection and a radially inwardly directed flange at one end of the cylindrical section define a plurality of circumferentially spaced, generally axial score lines extending from the edge of the cylindrical section opposite the one end and terminates at the juncture of the flange and cylindrical section.
摘要翻译： 用于将封闭件固定在容器开口端的防篡改环。 封盖和容器具有可由环接合的突起，该突起包括环形构件，其在施加到容器 - 封闭组件之前具有直径略大于容器的最大横向尺寸的大致圆柱形部分。 闭合突起和在圆柱形部分的一端处的径向向内的凸缘限定了多个周向间隔开的大致轴向的刻痕线，其从圆柱形部分的与一端相对的边缘延伸，并终止于凸缘和圆柱形部分的接合处 。
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公开(公告)号：US4784279A
公开(公告)日：1988-11-15
申请号：US80409
申请日：1987-07-31
CPC分类号： B65D55/0845
摘要： A tamper-proof seal for a container having at least one circumferentially extending flange adjacent the discharge opening therein comprising an annular top and a circumferentially extending skirt depending from the top adapted to be crimped at its lower terminal edge to engage under the flange to hold it on the container. A pull ring connects to the annular portion by a throat portion and partial score lines extend across the annular top portion on either side of the pull ring and define a plurality of circumferentially spaced score lines extending from the lower edge of the skirt upwardly in an axial direction to a point closely adjacent the juncture of the skirt and annular top portion. The axial score lines are spaced closely about the skirt.
摘要翻译： 用于容器的防篡改密封件，其具有邻近其排出开口的至少一个周向延伸的凸缘，其包括环形顶部和从顶部垂下的周向延伸的裙部，其适于在其下端部边缘处被压接以在凸缘下方接合以保持 在容器上 拉环通过喉部连接到环形部分，并且部分刻痕线延伸穿过拉环的任一侧上的环形顶部，并限定多个周向间隔开的刻痕线，其从裙部的下边缘向上以轴向延伸 方向到靠近裙部和环形顶部的接合处的点。 轴向刻痕线围绕裙部紧密地隔开。
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公开(公告)号：US4471879A
公开(公告)日：1984-09-18
申请号：US520186
申请日：1983-08-04
CPC分类号： B65D51/002
摘要： This invention relates to an overcap for pharmaceutical and similar containers which enables an immediate determination to be made whether or not the container has been tampered with or if an additive has been injected into the containers.
摘要翻译： 本发明涉及用于药物和类似容器的顶盖，其能够立即确定容器是否被篡改，或者添加剂是否被注入到容器中。
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