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    Stannous Salt and Sodium Tripolyphosphate Oral Care Compositions and Methods
    1.
    发明申请
    Stannous Salt and Sodium Tripolyphosphate Oral Care Compositions and Methods 有权
    亚锡盐和三聚磷酸钠口腔护理组合物和方法

    公开(公告)号：US20080286214A1

    公开(公告)日：2008-11-20

    申请号：US12094817

    申请日：2006-11-21

    Applicant: James R. Brown ,  Linh Fruge ,  Tao Xu ,  Michael Prencipe

    Inventor： James R. Brown ,  Linh Fruge ,  Tao Xu ,  Michael Prencipe

    IPC: A61K8/21 ,  A61K8/24 ,  A61Q11/00

    CPC classification number: A61K8/21 ,  A61K8/03 ,  A61K8/19 ,  A61K8/20 ,  A61K8/24 ,  A61K8/25 ,  A61K8/55 ,  A61K8/69 ,  A61K8/8164 ,  A61K2800/28 ,  A61K2800/591 ,  A61Q11/00

    Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.

    Abstract translation: 提供含有亚锡盐和三聚磷酸钠的口腔护理组合物，其中三聚磷酸三钠离子中间体包含少于组合物的约1％焦磷酸四钠，甲基乙烯基醚 - 马来酸酐共聚物和/或二氧化硅口服抛光剂可用于进一步的功效 。 在单相共混物中，口腔护理组合物可以有效地限制为包含小于约10％的水。 在双相混合物中，在牙齿保健使用之前，可以从双室存储管（每个相位由独立的室提供）产生具有第一相中的亚锡盐和第二相中的三聚磷酸钠的混合物。

    Stannous salt and sodium tripolyphosphate oral care compositions and methods
    2.
    发明授权
    Stannous salt and sodium tripolyphosphate oral care compositions and methods 有权
    亚锡盐和三聚磷酸钠口腔护理组合物和方法

    公开(公告)号：US08481004B2

    公开(公告)日：2013-07-09

    申请号：US12094817

    申请日：2006-11-21

    Applicant: James R. Brown ,  Linh Fruge ,  Tao Xu ,  Michael Prencipe

    Inventor： James R. Brown ,  Linh Fruge ,  Tao Xu ,  Michael Prencipe

    IPC: A61K8/00 ,  A61K6/00 ,  A61Q11/00

    CPC classification number: A61K8/21 ,  A61K8/03 ,  A61K8/19 ,  A61K8/20 ,  A61K8/24 ,  A61K8/25 ,  A61K8/55 ,  A61K8/69 ,  A61K8/8164 ,  A61K2800/28 ,  A61K2800/591 ,  A61Q11/00

    Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.

    Abstract translation: 提供含有亚锡盐和三聚磷酸钠的口腔护理组合物，其中三聚磷酸三钠离子中间体包含少于组合物的约1％焦磷酸四钠，甲基乙烯基醚 - 马来酸酐共聚物和/或二氧化硅口服抛光剂可用于进一步的功效 。 在单相共混物中，口腔护理组合物可以有效地限制为包含小于约10％的水。 在双相混合物中，在牙齿保健使用之前，可以从双室存储管（每个相位由独立的室提供）产生具有第一相中的亚锡盐和第二相中的三聚磷酸钠的混合物。

    Two phase toothpaste composition
    5.
    发明申请
    Two phase toothpaste composition 有权
    两相牙膏组成

    公开(公告)号：US20060140879A1

    公开(公告)日：2006-06-29

    申请号：US11023968

    申请日：2004-12-28

    Applicant: Linh Fruge ,  James Brown ,  Susan Herles ,  Kimberlee Panaligan ,  Evangelia Arvanitidou ,  Nebojsa Milanovich ,  Michael Prencipe

    Inventor： Linh Fruge ,  James Brown ,  Susan Herles ,  Kimberlee Panaligan ,  Evangelia Arvanitidou ,  Nebojsa Milanovich ,  Michael Prencipe

    IPC: A61K8/21

    CPC classification number: A61K8/21 ,  A61K8/19 ,  A61K8/347 ,  A61K2800/88 ,  A61Q11/00

    Abstract: An oral care composition having a first phase of clinically efficacious 2,4,4′-trichloro 2′-hydroxydiphenyl ether admixed in a first orally acceptable aqueous vehicle, and a second phase having a stannous salt (such as stannous fluoride) admixed in a second orally acceptable aqueous vehicle. The second phase has no less than 10 molar percent of soluble stannous ion respective to a mathematical sum of moles of the soluble stannous ion and moles of the stannous salt in the second phase. In one embodiment, the two phases are provided in a dual-tube toothpaste oral care kit.

    Abstract translation: 一种口腔护理组合物，其具有混合在第一口服可接受的水性载体中的临床上有效的2,4,4'-三氯2'-羟基二苯醚的第一相，和在其中混合的具有亚锡盐（例如氟化亚锡）的第二相 第二种口服可接受的水性载体。 第二相具有不少于10摩尔％的可溶性亚锡离子，相对于第二相中可溶性亚锡离子的摩尔数和亚锡盐的摩尔数的数学和。 在一个实施方案中，将两相设置在双管牙膏口腔护理套件中。

    Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
    7.
    发明申请
    Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives 审中-公开
    包含酚类化合物和抗氧化维生素和维生素衍生物的口腔护理组合物

    公开(公告)号：US20060120975A1

    公开(公告)日：2006-06-08

    申请号：US11238522

    申请日：2005-09-29

    Applicant: Dale Scherl ,  Kimberlee Panaligan ,  Linh Fruge ,  Harsh Trivedi ,  Tao Xu

    Inventor： Dale Scherl ,  Kimberlee Panaligan ,  Linh Fruge ,  Harsh Trivedi ,  Tao Xu

    IPC: A61K8/49

    CPC classification number: A61K8/347 ,  A61K8/498 ,  A61K8/676 ,  A61K8/678 ,  A61K31/085 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/555 ,  A61Q11/00

    Abstract: An oral care composition comprises an antibacterial phenolic compound and a vitamin or vitamin derivative component comprising one to a plurality of antioxidant vitamin or vitamin derivatives. In one embodiment the vitamin or vitamin derivative component comprises vitamin E and vitamin E acetate and optionally one or more additional vitamin or vitamin derivatives. In another embodiment the vitamin or vitamin derivative component comprises an antioxidant vitamin or vitamin derivative and a source of vitamin B5. A method of oral care comprises applying a composition as described above to an oral surface of a subject.

    Abstract translation: 口腔护理组合物包含抗菌酚类化合物和包含一种至多种抗氧化维生素或维生素衍生物的维生素或维生素衍生物组分。 在一个实施方案中，维生素或维生素衍生物组分包含维生素E和维生素E乙酸酯和任选的一种或多种另外的维生素或维生素衍生物。 在另一个实施方案中，维生素或维生素衍生物组分包含抗氧化维生素或维生素衍生物和维生素B 5的来源。 口腔护理的方法包括将如上所述的组合物施用于受试者的口腔表面。

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