公开(公告)号：USRE30712E

公开(公告)日：1981-08-18

申请号：US45420

申请日：1979-06-04

Applicant: James H. Macemon

Inventor： James H. Macemon

IPC: G01J3/44

CPC classification number: G01J3/4406

Abstract: A system for plotting the total luminescence spectrum of a sample comprises a spectrofluorometer including excitation and emission monochromator stages having operating wavelengths dependent on applied stepping pulses, and an X-Y plotter having a marking pen synchronized for movement along X and Y axis with changes in the wavelengths of the monochromators. A control circuit generates pulses to incrementally step the emission monochromator and horizontally scan the marking pen. A level detection circuit monitors the output of the spectroflourometer and activates the pen upon attainment of a desired contour level. Limit circuitry incorporated in the control circuit momentarily actuates the excitation monochromator following each horizontal scan to increase the excitation wavelength for the subsequent emission scan to complete the plot.

公开(公告)号：US4090789A

公开(公告)日：1978-05-23

申请号：US702473

申请日：1976-07-06

Applicant: James H. Macemon ,  Charles Soodak

Inventor： James H. Macemon ,  Charles Soodak

IPC: G01N21/13 ,  G01N21/25 ,  G01J3/30

CPC classification number: G01N21/253 ,  G01N2201/0415

Abstract: Cuvette positioning apparatus for use in a spectrophotometer adapted for comparing first and second material samples includes a carrier in which cuvettes to be alternately analyzed are arranged end-to-end. The carrier is reciprocated along a vertical axis to expose the cuvettes in alternation to the monochromatic beam of the apparatus. The rate of reciprocation is selected to avoid cavitation of the samples, and a sinusoidal drive arrangement increases the exposure time of the samples to the light beam and minimizes transit time for optimum measurement efficiency. Circuitry responsive to synchronizing signals derived from the drive arrangement is utilized to form an output signal indicative of the difference in measured characteristics between the samples.

Abstract translation: 用于比较第一和第二材料样品的分光光度计中的比色杯定位装置包括载体，其中交替分析的比色杯端对端地排列。 载体沿着垂直轴线往复运动，以使试管与设备的单色光束交替地暴露。 选择往复运动的速率以避免样品的气蚀，并且正弦驱动装置增加了样品对光束的曝光时间，并将传播时间最小化以获得最佳的测量效率。 利用响应于从驱动装置导出的同步信号的电路来形成指示样本之间的测量特性差异的输出信号。

公开(公告)号：US20100168535A1

公开(公告)日：2010-07-01

申请号：US12714100

申请日：2010-02-26

Applicant: Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

Inventor： Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61M5/16831 ,  A61M2005/1404 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2230/201

Abstract: The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.

Abstract translation: 本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。 血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。 本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。 本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。 一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。 本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。 此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。 本发明不消耗大量的血液。 本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

公开(公告)号：US06969419B1

公开(公告)日：2005-11-29

申请号：US10474101

申请日：2000-05-05

Applicant: James H. Macemon

Inventor： James H. Macemon

IPC: B01D19/00 ,  B01D19/02

CPC classification number: B01D19/0005

Abstract: A method for removing bubbles adhering to the interior wall of a fluid-filled chamber through which a fluid flows, and a related method and apparatus for removing bubbles from a chamber having medical sensory equipment such as a blood gas and chemistry analyzer. The method includes drawing a quantity of gas into the chamber to empty the chamber of fluid, maintaining the chamber in an empty state for a predetermined period of time, and then refilling the chamber with fluid at a rate low enough to remove remaining bubbles and to prevent the formation and trapping of new bubbles within the chamber.

Abstract translation: 用于去除附着在流体流过的流体填充室的内壁上的气泡的方法以及用于从具有诸如血液气体和化学分析仪的医学感觉设备的室中除去气泡的相关方法和装置。 该方法包括将一定数量的气体抽入腔室以清空流体室，将腔室保持在空的状态一段预定的时间，然后以足够低的速率用流体重新填充腔室以除去剩余的气泡，并且 防止在室内形成和捕获新的气泡。

公开(公告)号：US3967113A

公开(公告)日：1976-06-29

申请号：US530053

申请日：1974-12-05

Applicant: Charles Soodak ,  James H. Macemon

Inventor： Charles Soodak ,  James H. Macemon

IPC: G01J3/443 ,  G01J3/44 ,  G01N21/64 ,  H01J39/12

CPC classification number: G01J3/4406

Abstract: A spectrofluorometer providing wavelength correction by means of an arbitrary function generator driven by a wavelength scanning element of the spectrofluorometer. The arbitrary function generator may be driven by the emission scanning monochromator to derive a wavelength-dependent voltage signal which is combined with the measure photomultiplier output to thereby provide a base-line compensated resultant output signal. Alternatively, the arbitrary function generator may be driven by the excitation scanning monochromator to derive a wavelength-dependent voltage signal which is combined with the output of a reference photomultiplier tube receiving part of the output of the excitation monochromator to derive an excitation-corrected reference signal which is in turn combined with the measure photomultiplier tube output signal to thereby provide an energy-corrected resultant output signal. An analog divider may be employed to divide this last-named resultant output signal by said excitation wavelength-dependent voltage signal to thereby derive a quantum-corrected fluorescence emission output signal. The arbitrary function generator has successive incremental wavelength range segments provided respectively with independently adjustable potentiometers to suitably shape the wavelength-dependent voltage signal curve.

Abstract translation: 一种分光荧光计，其通过由分光荧光计的波长扫描元件驱动的任意函数发生器提供波长校正。 任意函数发生器可以由发射扫描单色仪驱动，以导出与测量光电倍增管输出组合的波长相关电压信号，从而提供基线补偿的合成输出信号。 或者，可以由激励扫描单色仪驱动任意函数发生器，以得到与波长相关的电压信号，该电压信号与接收激励单色仪输出的一部分的参考光电倍增管的输出相结合，以导出激励校正参考信号 其结合测量光电倍增管输出信号，从而提供能量校正的结果输出信号。 可以使用模拟分频器来将所述最终命名的合成输出信号除以所述激发波长相关电压信号，从而导出量子校正的荧光发射输出信号。 任意函数发生器具有分别提供独立可调节的电位计的连续增量波长范围段，以适当地形成与波长相关的电压信号曲线。

公开(公告)号：US5511880A

公开(公告)日：1996-04-30

申请号：US312766

申请日：1994-09-27

Applicant: James H. Macemon

Inventor： James H. Macemon

IPC: B01F9/00 ,  B01F11/00 ,  B01L9/06

CPC classification number: B01F9/002 ,  B01F11/0002 ,  B01L9/06

Abstract: A mixing device includes a plurality of elongated ampules mounted on a rotatable support with the longitudinal axis of each ampule inclined inwardly toward the rotational axis of the rotatable support. When the mixing device rotates about the rotational support, centrifugal force causes fluid in each ampule to move toward the end farthest away from the rotatable support. A bubble in each ampule then moves toward the opposite end. In one embodiment, the rotational support is inclined so that the end of each ampule positioned farthest from the rotational support is positioned sufficiently above the other end so that the bubble rises to the end farther from the support in at least one position as the support rotates. As a result, a bubble in each ampule moves back and forth between the ends of the ampule as the rotatable support rotates to mix respective fluids in the ampules. In another embodiment, the ampules are pivotably mounted on the elongated support so that opposite ends are alternately positioned farthest from the support, thereby causing a bubble to move back and forth in each ampule. A chamber for collecting a blood sampling may be positioned on the rotatable support for subsequent analysis by an analysis machine that uses the fluids in the ampules for calibrating and washing purposes.

Abstract translation: 混合装置包括安装在可旋转支撑件上的多个细长安瓿，每个安瓿的纵向轴线朝向可旋转支撑件的旋转轴线向内倾斜。 当混合装置围绕旋转支撑件旋转时，离心力使得每个安瓿中的流体朝向远离可旋转支撑件最远的一端移动。 每个安瓿中的气泡然后向另一端移动。 在一个实施例中，旋转支撑件是倾斜的，使得位于最远离旋转支撑件的每个安瓿的端部被充分地定位在另一端的上方，使得当支撑件旋转时，气泡在至少一个位置中从支撑件上升到更远的一端 。 结果，随着可旋转支撑件旋转以混合安瓿中的各个流体，每个安瓿中的气泡在安瓿的端部之间来回移动。 在另一个实施例中，安瓿可枢转地安装在细长支撑件上，使得相对的端部交替地定位成离支撑件最远，从而使气泡在每个安瓿中来回移动。 用于收集血液取样的腔室可以定位在可旋转的支撑件上，以便由使用安瓿中的流体进行校准和洗涤目的的分析机进行随后的分析。

公开(公告)号：US5143084A

公开(公告)日：1992-09-01

申请号：US615747

申请日：1990-11-16

Applicant: James H. Macemon ,  Mark S. Schlosser

Inventor： James H. Macemon ,  Mark S. Schlosser

IPC: A61B5/15 ,  A61B5/155 ,  B01L3/14

CPC classification number: B01L3/5082 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/153 ,  A61B5/157 ,  A61B5/150251 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150503

Abstract: A disposable sampling cartridge for use with a blood sample analyzer. The cartridge includes a blood reservoir communicating with a hypodermic needle, a waste collection chamber adapted to receive waste fluids from the blood sample analyzer, and a plurality of ampules each containing a respective analyzing fluid adapted for use by the blood sample analyzer. Each of the ampules contain a piston, and the analyzing fluids in the ampules are expelled by forcing an actuating rod through a frangible wall of the ampule to displace the piston. In one embodiment, the analyzing fluids are withdrawn through a conduit in the actuating rod while the blood and spent analyzing fluids flow through the blood reservoir port on which the hypodermic needle is mounted. In another embodiment the waste fluid flows through an inlet port while the analyzing fluids from the ampules flow through a common port outlet port which selectively communicates with the blood reservoir and the ampules by a valve arrangement.

Abstract translation: 用于血液样本分析仪的一次性取样盒。 药筒包括与皮下注射针连通的血液储存器，适于接收来自血液样本分析器的废液的废物收集室，以及多个安瓿，每个安瓿含有适于由血液样本分析仪使用的各自的分析流体。 每个安瓿都包含一个活塞，并且安瓿中的分析流体通过迫使致动杆穿过安瓿的易碎壁来移动活塞而排出。 在一个实施例中，分析流体通过致动杆中的导管被抽出，同时血液和废分析流体流过其上安装有皮下注射针的血液储存口。 在另一个实施方案中，废液流过入口，而来自安瓿的分析流体流过公共端口出口，其通过阀装置选择性地与血液储存器和安瓿连通。

公开(公告)号：USD247226S

公开(公告)日：1978-02-14

申请号：US689436

申请日：1976-05-24

Applicant: James G. Bruni ,  Stephen G. Hauser ,  David L. Lessner ,  James H. Macemon

Designer： James G. Bruni ,  Stephen G. Hauser ,  David L. Lessner ,  James H. Macemon

公开(公告)号：US4239391A

公开(公告)日：1980-12-16

申请号：US29317

申请日：1979-04-12

Applicant: David L. Lessner ,  James H. Macemon ,  George M. Coker, Jr ,  Charles E. Hodgson

Inventor： David L. Lessner ,  James H. Macemon ,  George M. Coker, Jr ,  Charles E. Hodgson

IPC: G01N21/64 ,  G02B7/00 ,  G01J3/30 ,  G01J4/00

CPC classification number: G02B7/005 ,  G01N21/6445 ,  G02B27/286 ,  G02B7/006

Abstract: The input polarizer and the output polarizer of a spectrofluorometer are each mechanically identical except for the optical elements, and are constructed as modules which plug into a spectrofluorometer base. Each of the polarizer modules includes a polarizing filter that is rotatable and a self-contained motor drive for rotating the polarizing filter. Each of the motor drives comprises an electric motor mounted on the respective module, a pulley mounted on the respective module and rotatable with actuation of the electric motor, a loop coupling the pulley to the polarizing filter for rotation of the filter with rotation of the pulley, and means for enabling the filter to rotate exactly 90.degree. in opposite directions.

Abstract translation: 除了光学元件之外，分光荧光计的输入偏振器和输出偏振器各自机械相同，并且被构造成插入分光荧光计基座的模块。 每个偏振器模块包括可旋转的偏振滤光器和用于旋转偏振滤光器的独立电机驱动器。 每个电动机驱动器包括安装在相应模块上的电动机，安装在相应模块上的滑轮并且可随着电动机的致动而旋转;将滑轮连接到偏振滤光器的环路，以使滤光器随着滑轮的旋转而旋转 ，以及使过滤器能够在相反方向正好旋转90度的装置。

公开(公告)号：US4047820A

公开(公告)日：1977-09-13

申请号：US687883

申请日：1976-05-19

Applicant: Charles Soodak ,  David L. Lessner ,  James H. Macemon

Inventor： Charles Soodak ,  David L. Lessner ,  James H. Macemon

IPC: G01N21/25 ,  G01N21/16

CPC classification number: G01N21/253

Abstract: A rotary sample changer for a spectrofluorometer has a revolving turret base which can be indexed and which carries an interchangeable sample carrier. Different sample carriers accommodate test cells, test tubes and cuvettes of different sizes and shapes.The revolving turret base and the interchangeable rotary sample carriers are constructed of material having good thermal conductivity and rotate on a large stationary hollow axle which is thermostated by thermally controlled internal fluid circulation to act as a heat source or sink to the samples. Thus, the sample carriers can readily be interchanged without disturbing the plumbing by which the thermostatic fluid is circulated.The revolving turret base is detented at the stations to which it is indexed without kinematic ambiguity and without application of any cocking force. Two spring biased ball detents, symmetrically spaced 180.degree. about the axis of rotation, are provided. At the four index stations one ball catches on one of two indexing grooves spaced 90.degree. apart, while the other ball bears against a flat.

Abstract translation: 用于分光荧光计的旋转取样器具有可转位的旋转转塔底座，并带有可互换的样品载体。 不同的样品载体适应不同尺寸和形状的测试细胞，试管和比色皿。