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    Somatostatin analogs and intermediates thereto
    4.
    发明授权
    Somatostatin analogs and intermediates thereto 失效
    生长抑素类似物及其中间体

    公开(公告)号：US4087390A

    公开(公告)日：1978-05-02

    申请号：US763944

    申请日：1977-02-02

    Applicant: James E. Shields

    Inventor： James E. Shields

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00 ,  C08L89/00

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16 ,  Y10S930/28

    Abstract: The tetradecapeptides ##STR1## in which Y is L-Asn or L-Ala are described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the tetradecapeptides. These tetradecapeptides as well as their pharmaceutically-acceptable acid addition salts exhibit various activities including inhibition of the release of gastric acid.

    Abstract translation: 其中Y是L-Asn或L-Ala的十四肽“IMAGE”以及相应的无毒的药学上可接受的酸加成盐以及可用于合成十四肽的中间体。 这些十四肽及其药学上可接受的酸加成盐显示出各种活性，包括抑制胃酸的释放。

    Peptides related to somatostatin
    8.
    发明授权
    Peptides related to somatostatin 失效
    与生长抑素有关的肽

    公开(公告)号：US4199501A

    公开(公告)日：1980-04-22

    申请号：US965536

    申请日：1978-11-20

    Applicant: James E. Shields

    Inventor： James E. Shields

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Tetradecapeptides of the formula ##STR1## wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly, and X.sup.1 is Phe or Cha, or a non-toxic pharmaceutically acceptable acid addition salt thereof, inhibit the secretion of growth hormone without materially inhibiting the secretion of glucagon or insulin. Intermediates and processes for making the tetradecapeptides are also described.

    Abstract translation: 其中X是H-Ala-D-Ala，HD-Ala-Gly或HD-Val-Gly，X1是Phe或Cha或其无毒的药学上可接受的酸加成盐的式（I）的十四肽， 抑制生长激素的分泌，而不会明显抑制胰高血糖素或胰岛素的分泌。 还描述了制备十四肽的中间体和方法。

    Somatostatin analogs and intermediates thereto
    9.
    发明授权
    Somatostatin analogs and intermediates thereto 失效
    生长抑素类似物及其中间体

    公开(公告)号：US4061607A

    公开(公告)日：1977-12-06

    申请号：US709465

    申请日：1976-07-28

    Applicant: James E. Shields

    Inventor： James E. Shields

    IPC: C07K14/575 ,  A61K38/00 ,  C07K14/655 ,  C08L67/00 ,  C07C103/52

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S930/16 ,  Y10S930/28

    Abstract: The tetradecapeptides ##STR1## in which Y is L-Cha, L-Leu, or D-Phe are described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the tetradecapeptides. These tetradecapeptides as well as their pharmaceutically-acceptable acid addition salts inhibit the release of growth hormone.

    Abstract translation: 其中Y是L-Cha，L-Leu或D-Phe的十四肽“IMAGE”以及相应的无毒的药学上可接受的酸加成盐以及可用于合成十四肽的中间体进行了描述。 这些十四肽及其药学上可接受的酸加成盐抑制生长激素的释放。

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