公开(公告)号：US20220281815A1

公开(公告)日：2022-09-08

申请号：US17733736

申请日：2022-04-29

申请人： JUBILANT BIOSYS LIMITED

发明人： Sridharan RAJAGOPAL ,  Mahanandeesha S. HALLUR ,  Purushottam DEWANG ,  Kannan MURUGAN ,  Durga Prasanna KUMAR C.H. ,  Pravin IYER ,  Chandrika MULAKALA ,  Dhanalakshmi SIVANANDHAN ,  Sreekala NAIR ,  Mohd ZAINUDDIN ,  Subramanyam Janardhan TANTRY ,  Chandru GAJENDRAN ,  Sriram RAJAGOPAL

IPC分类号： C07D205/12 ,  A61P35/00 ,  C07C235/56 ,  C07C237/20 ,  C07C259/08 ,  C07D205/04 ,  C07D211/26 ,  C07D217/18 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  C07D209/44

摘要： The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.