公开(公告)号：US20230383037A1

公开(公告)日：2023-11-30

申请号：US18248565

申请日：2021-10-11

申请人： JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

发明人： Shinji SAKUMA ,  Takumi TOMONO ,  Kohei MIYATA ,  Koichi SHIGENO

IPC分类号： C08F222/38 ,  A61K47/36 ,  A61K47/34

CPC分类号： C08F222/38 ,  A61K47/36 ,  A61K47/34

摘要： The object of the present invention is to provide an absorption enhancer capable of introducing high-molecular weight compounds into cells.
The object can be solved by a composition of the present invention comprising a polymer compound having a group represented by the following general formula (1) or the following general formula (2) at a side chain, and a compound to be administered with a molecular weight of 1,000 to 1,200,000.




wherein X1 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X2 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X3 is a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms or a benzyloxy group, a is an integer of 0 to 50, and * denotes a bonding site.




wherein X4 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X5 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X6 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group or an oxycarbonyl group, b is an integer of 0 to 50, and * denotes a bonding site.