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公开(公告)号：US20240109974A1
公开(公告)日：2024-04-04
申请号：US18274845
申请日：2022-01-27
发明人： Xiaofeng ZHAO , Shiqiang LU , Zhuoxiao CAO , Renhong TANG , Jinsheng REN
CPC分类号： C07K16/2878 , A61K39/4631 , A61P35/00 , C12N15/63 , A61K2239/13 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/526 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Disclosed in the present invention are a humanized antibody that can specifically bind to TNFR2, or an antigen-binding fragment thereof. The humanized antibody or antigen-binding fragment thereof can regulate the function of immune cells and can be used in a drug for treating diseases related to immune abnormalities, such as tumours.
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公开(公告)号：US20230192797A1
公开(公告)日：2023-06-22
申请号：US17925547
申请日：2021-05-17
发明人： Jing DENG , Shiqiang LU , Yang LIU , Zhuoxiao CAO , Renhong TANG , Jinsheng REN
CPC分类号： C07K14/5443 , C07K16/2827 , C07K14/7155 , A61K38/2086 , A61K45/06 , A61P35/00 , A61P17/00 , C07K2317/92 , C07K2317/76 , C07K2319/30 , C07K2317/24 , A61K2039/505
摘要： Provided are a human IL-15 molecule mutant and a fusion protein containing the IL-15 mutant and combined mutations, wherein the fusion protein can mediate the activation and amplification of immune cells and can be used for treating tumor disease
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公开(公告)号：US20240307415A1
公开(公告)日：2024-09-19
申请号：US18573968
申请日：2022-06-23
发明人： Lifeng LIU , Zhen LI , Xiaoqing LIU , Xiaofeng ZHAO , Xiaojuan CHA , Feng TANG , Yayuan FU , Zhuoxiao CAO , Renhong TANG , Jinsheng REN
CPC分类号： A61K31/58 , A61P5/46 , C07J71/0031
摘要： A compound as represented by formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof, a preparation method therefor, and the use thereof in the treatment of tumors, inflammatory diseases or autoimmune diseases.
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