公开(公告)号：US20240317892A1

公开(公告)日：2024-09-26

申请号：US17440299

申请日：2020-03-20

申请人： JAVELIN ONCOLOGY, INC

发明人： Anthony B. Cooper

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C12N5/0783

CPC分类号： C07K16/40 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464458 ,  A61P35/00 ,  C12N5/0636 ,  C07K2317/24 ,  C12N2510/00

摘要： Anti-ADAM12 agents are provided such as anti-ADAM12 antibodies (Abs), antigen-binding Ab fragments, multi-specific Abs and antigen-binding Ab fragments, antibody-drug conjugates (ADCs), and chimeric antigen receptors (CARs). Also, nucleic acid sequences and vectors are provided encoding, cells and pharmaceutical compositions comprising such anti-ADAM12 agents and methods for expanding such cells. Methods of treating, preventing, or diagnosing a disease such as cancer and methods of stimulating an immune response using such materials are also provided.