公开(公告)号：US20230321366A1

公开(公告)日：2023-10-12

申请号：US18022917

申请日：2021-08-31

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： David RAMOS ,  Shagun POPLI ,  Michael CANNAMELA ,  Jimmy Vinh Hoang CASSEBEE ,  Hong YAN ,  Dolores PEREZ ,  Jingli WANG ,  Chaley John LARSON ,  Ian SCRIMGEOUR ,  Emma Louise HUBERT ,  Monica A. KAPIL ,  Sreven M. VESOLE

IPC: A61M11/00 ,  A61M15/08

CPC classification number: A61M11/007 ,  A61M15/085 ,  A61M2205/073 ,  A61M2210/0618

Abstract: Various exemplary drug delivery devices with a mechanical stop, drug products utilizing the same, and methods of using drug delivery devices with a mechanical stop are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.

公开(公告)号：US20230310752A1

公开(公告)日：2023-10-05

申请号：US18022910

申请日：2021-08-31

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Emma Louise HUBERT ,  Ian SCRIMGEOUR ,  David RAMOS ,  Steven M. VESOLE ,  Monica A. KAPIL ,  William C. GEARY ,  Shagun POPLI ,  Michael CANNAMELA ,  Jimmy Vinh Hoang CASSEBEE ,  Hong YAN ,  Dolores PEREZ

IPC: A61M5/315

CPC classification number: A61M5/31563 ,  A61M5/31578 ,  A61M5/3134

Abstract: Various exemplary drug syringes with a mechanical stop for a second dose, drug products utilizing the same, and methods of using drug syringes with a mechanical stop for a second dose are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.

公开(公告)号：US20230263972A1

公开(公告)日：2023-08-24

申请号：US18023637

申请日：2021-09-01

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Emma Louise HUBERT ,  Monica A. KAPIL ,  MingQi ZHAO ,  Steven M. VESOLE ,  Ian SCRIMGEOUR ,  David RAMOS ,  Jaskaran SINGH ,  Jingli WANG ,  David KALIKHMAN ,  Shagun POPLI ,  Peter KRULEVITCH ,  Hong YAN ,  Michael A. BARATTA ,  Whitney PHILLIPS ,  Francesco N. ALBERTINI ,  Michael CANNAMELA

IPC: A61M15/08 ,  A61M11/00

CPC classification number: A61M15/08 ,  A61M11/007 ,  A61M2205/273 ,  A61M2205/3368 ,  A61M2205/3324

Abstract: Various exemplary drug delivery devices with on-board drug destruction, drug products utilizing the same, and methods of using drug delivery devices with on-board drug destruction are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom into a nose includes a destruction mechanism configured to destroy drug contained in the drug delivery device. The destruction mechanism can be configured to destroy the drug before a first actuation of the drug delivery device to deliver the drug therefrom such that the destruction mechanism destroys substantially all of the drug contained in the drug delivery device. Alternatively or in addition, the destruction mechanism can be configured to destroy the drug after a first actuation of the drug delivery device to deliver the drug therefrom such that the destruction mechanism destroys substantially all of the drug remaining in the drug delivery device.

公开(公告)号：US20230310763A1

公开(公告)日：2023-10-05

申请号：US18024100

申请日：2021-08-31

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： David SHEPHERD ,  Scott MARTIN ,  Michael CANNAMELA ,  Jimmy Vinh Hoang CASSEBEE ,  Hong YAN ,  Dolores PEREZ ,  Shagun POPLI ,  Emma Louise HUBERT ,  Steven M. VESOLE

IPC: A61M15/00 ,  A61M15/08 ,  A61M11/06

CPC classification number: A61M15/0003 ,  A61M15/08 ,  A61M15/0028 ,  A61M11/06

Abstract: Various exemplary drug delivery devices with multiple drug vials, drug products utilizing the same, and methods of using drug delivery devices with multiple drug vials are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom into a nose and includes two or more vials each containing the drug therein. The drug delivery device is configured to deliver the drug from each of the vials for a total of two or more sprays into the nose. The same drug delivery device may therefore deliver multiple drug sprays to a user. In some embodiments, instead of including two or more vials that collectively contain enough drug therein for more than two drug sprays, the drug delivery device can include a single vial that contains enough drug therein for more than two drug sprays.

公开(公告)号：US20230037529A1

公开(公告)日：2023-02-09

申请号：US17786324

申请日：2020-12-17

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Michael CANNAMELA ,  Emma Louise HUBERT

IPC: B65D75/36

Abstract: Various packaging systems and packaging kits are described. In one exemplary embodiment, a packaging system is provided and includes a base configured to receive a drug delivery device having a device body having an upper segment and a lower segment, and an actuator. The base is configured to house the received drug delivery device therein at a non-zero angle relative to a longitudinal axis of the base. The base includes a retaining cavity and a gripping cavity adjacent the retaining cavity. The retaining cavity is configured to create an interference fit with at least a portion of an upper segment of a drug delivery device received within the base, and the gripping cavity is configured to receive a lower segment of a device body and a portion of an actuator of a drug delivery device received within the base.

公开(公告)号：US20240009409A1

公开(公告)日：2024-01-11

申请号：US18023649

申请日：2021-09-01

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Michael CANNAMELA ,  Hong YAN ,  Dolores PEREZ ,  Jimmy Vinh Hoang CASSEBEE ,  Emma Louise HUBERT ,  Steven M. VESOLE ,  Shagun POPLI ,  Jingli WANG

IPC: A61M15/00 ,  A61M15/08 ,  A61M11/00

CPC classification number: A61M15/0003 ,  A61M15/0028 ,  A61M15/08 ,  A61M11/006 ,  A61M2205/50

Abstract: Various exemplary drug delivery devices (500, 700) with reusable components (512, 702) and disposable components (504, 704, 706), drug products utilizing the same, and methods of using drug delivery devices with reusable components and disposable components are provided. In general, a nasal drug delivery device is configured to deliver a drug therefrom and includes one or more disposable components and one or more reusable components. The one or more disposable components are releasably coupled to the one or more reusable components. After the drug is delivered from the drug delivery device, the one or more disposable components can be detached from the one or more reusable components. Another one or more disposable components can then be releasably coupled to the one or more reusable components and the drug delivery device used to again deliver a drug therefrom.

公开(公告)号：US20230321367A1

公开(公告)日：2023-10-12

申请号：US18024093

申请日：2021-08-31

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Michael CANNAMELA ,  Jimmy Vinh Hoang CASSEBEE ,  Hong YAN ,  Christina SPERRY ,  Dolores PEREZ ,  Chaley John LARSON ,  Steven M. VESOLE ,  Emma Louise HUBERT

IPC: A61M11/00 ,  A61M15/00

CPC classification number: A61M11/007 ,  A61M15/0003 ,  A61M15/0051 ,  A61M15/004 ,  A61M2210/0618

Abstract: A drug delivery device (400) comprises a tip (416) configured to be positioned in a nose of a patient, the tip having an opening (414) therein, a coupling mechanism (402) configured to releasably couple to a first vial (404) containing a first drug therein, to release the first vial therefrom, and to subsequently be releasably coupled to a second vial containing a second drug therein, and a plunger configured to be actuated to cause the first drug to exit through the opening and to be subsequently actuated to cause the second drug to exit through the opening. The same drug delivery device is therefore configured to deliver multiple doses. There are also disclosed various exemplary reloadable drug vials for multi-dose delivery, drug products utilizing the same, and methods of using reloadable drug vials for multi-dose delivery.

公开(公告)号：US20230310767A1

公开(公告)日：2023-10-05

申请号：US18023632

申请日：2021-09-01

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Emma Louise HUBERT ,  Hong YAN ,  David RAMOS ,  Shagun POPLI ,  Steven M. VESOLE ,  Jingli WANG ,  Michael CANNAMELA ,  Dolores PEREZ ,  Jimmy Vinh Hoang CASSEBEE

IPC: A61M15/08 ,  A61M15/00 ,  A61M11/00

CPC classification number: A61M15/08 ,  A61M15/0003 ,  A61M15/0035 ,  A61M11/007

Abstract: Various exemplary drug holders (102, 200) for drug delivery devices (100), drug products utilizing the same, and methods of using drug holders for drug delivery devices are provided. In general, a nasal drug delivery device is configured to dispense therefrom at least one dose of a drug therefrom into a nose. The drug delivery device includes a drug holder that contains the drug therein that is delivered out of the drug delivery device. The drug holder can include two cavities (208, 210) therein that are fluidically sealed from one another prior to use of the drug delivery device to cause drug delivery. A first one of the cavities includes the drug therein, and a second one of the cavities includes a drug or air therein.

公开(公告)号：US20230270957A1

公开(公告)日：2023-08-31

申请号：US18024104

申请日：2021-08-31

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Ian SCRIMGEOUR ,  Emma Louise HUBERT ,  Shagun POPLI ,  Michael CANNAMELA ,  Monica A. KAPIL ,  Steven M. VESOLE

IPC: A61M15/00

CPC classification number: A61M15/0083 ,  A61M2205/276 ,  A61M2210/0618

Abstract: Various exemplary drug delivery devices with lock-out before drug delivery, drug products utilizing the same, and methods of using drug delivery devices with lock-out before drug delivery are provided. In general, a nasal drug delivery device is configured to dispense a drug therefrom into a nose and is configured to be releasably coupled to an accessory. The accessory is a separate, independent member from the drug delivery device such that in its decoupled state, the accessory is completely removed from the drug delivery device.