公开(公告)号：US11952411B2

公开(公告)日：2024-04-09

申请号：US17405872

申请日：2021-08-18

Applicant: JANSSEN BIOTECH, INC.

Inventor： Adam Zwolak ,  Szeman Chan ,  Rajkumar Ganesan

IPC: C07K14/705 ,  A61K38/00 ,  A61P37/04 ,  C07K14/765

CPC classification number: C07K14/70575 ,  A61P37/04 ,  C07K14/765 ,  A61K38/00 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/74

Abstract: Described herein are compositions and kits that comprise an engineered TL1A ligand that displays high stability, minimal binding to decoy receptor DcR3 while retaining functional activity via binding to its cell surface receptor, DR3, and the ability to activate T cells in vitro and in vivo. Methods of making an engineered TL1A ligand and methods of treating a disease or disorder in a subject by administering an engineered TL1A ligand are also provided.