公开(公告)号：US20200048349A1

公开(公告)日：2020-02-13

申请号：US16418082

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Francois GAUDET ,  Jill GILES-KOMAR ,  Bradley HEIDRICH ,  Chichi HUANG ,  Colleen KANE ,  Ronan MCDAID ,  Jennifer NEMETH-SEAY

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61P35/00

Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The present invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.

公开(公告)号：US20170210799A1

公开(公告)日：2017-07-27

申请号：US15409630

申请日：2017-01-19

Applicant: JANSSEN BIOTECH, INC.

Inventor： Glenn Mark ANDERSON ,  Eric T. BALDWIN ,  Benjamin HARMAN ,  Rosa M.F. CARDOSO ,  Jennifer F. NEMETH-SEAY ,  Ricardo ATTAR ,  Francois GAUDET ,  Yingzhe LI ,  Jinquan LUO ,  Ronan MCDAID ,  Steven C. POMERANTZ ,  Susan H. TAM ,  Alexey TEPLYAKOV ,  Sheng-Jiun WU

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

Abstract: Provided herein are isolated antibodies that immunospecifically bind to ROR1, bispecific antibodies comprising an antigen-binding site that immunospecifically binds to ROR1 and an antigen-binding site that immunospecifically binds to CD3, and methods of using the same.