公开(公告)号：US20230019640A1

公开(公告)日：2023-01-19

申请号：US17630706

申请日：2020-07-31

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Bharathikumar Vellalore MARUTHACHALAM ,  Adam ZWOLAK ,  Brian GEIST ,  Xiefan LIN-SCHMIDT ,  Sathyadevi VENKATARAMANI ,  Sanjaya SINGH

IPC: C07K16/28 ,  A61K47/68 ,  A61P11/00

Abstract: VHH domains that bind to p1gR are described. The VHH domain may compete with IgA binding to p1gR, or alternatively, the VHH domain may compete with IgA binding to p1gR. The VHH domains may be coupled to therapeutic agents so as to facilitate delivery of the therapeutic agent to the mucosal layer via p1gR-mediated transcytosis. The therapeutic agent can be a small molecule, large molecule, or even an antibody.

公开(公告)号：US20220324970A1

公开(公告)日：2022-10-13

申请号：US17630718

申请日：2020-07-31

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Bharathikumar Vellalore MARUTHACHALAM ,  Adam ZWOLAK ,  Brian GEIST ,  Xiefan LIN-SCHMIDT ,  Sathyadevi VENKATARAMANI ,  Sanjaya SINGH

IPC: C07K16/28 ,  A61K47/68 ,  A61K47/65

Abstract: A method is described for delivering a single domain antibody or a therapeutic molecule from an apical surface of a polymeric immunoglobulin receptor (pIgR)-expressing cell to a basolateral surface of the pIgR-expressing cell comprising contacting the pIgR-expressing cell with the single domain antibody or the therapeutic molecule, wherein the single domain antibody binds to pIgR, and the therapeutic molecule comprises an agent and the single domain antibody. A method is also described for transporting such a therapeutic molecule to systemic circulation or lamina propria or gastrointestinal tract of a subject comprising administering the therapeutic molecule to the subject via oral delivery, buccal delivery, nasal delivery or inhalation delivery.