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公开(公告)号：US20210054081A1
公开(公告)日：2021-02-25
申请号：US17080017
申请日：2020-10-26
Applicant: Invectys SA
Inventor： Pierre LANGLADE DEMOYEN , Thierry HUET , Julien CAUMARTIN , Maria LOUSTAU , Maria WEHBE
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
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公开(公告)号：US20230250175A1
公开(公告)日：2023-08-10
申请号：US18047988
申请日：2022-10-19
Applicant: Invectys SA
Inventor： Maria LOUSTAU , François ANNA , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
IPC: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2833 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C12N5/0637 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2319/03
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G β2M-free or β2M-associated immunosuppressive isoforms respectively.
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公开(公告)号：US20210040217A1
公开(公告)日：2021-02-11
申请号：US17077502
申请日：2020-10-22
Applicant: Invectys SA
Inventor： Maria LOUSTAU , Anna FRANCOIS , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
IPC: C07K16/28 , C07K14/705 , C07K14/725 , C12N5/0783
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G β2M-free or β2M-associated immunosuppressive isoforms respectively.
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公开(公告)号：US20220281981A1
公开(公告)日：2022-09-08
申请号：US17739596
申请日：2022-05-09
Applicant: Invectys SA
Inventor： Maria LOUSTAU , François ANNA , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
IPC: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G β2M-free or β2M-associated immunosuppressive isoforms respectively.
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公开(公告)号：US20220251216A1
公开(公告)日：2022-08-11
申请号：US17728483
申请日：2022-04-25
Applicant: Invectys SA
Inventor： Pierre LANGLADE DEMOYEN , Thierry HUET , Julien CAUMARTIN , Maria LOUSTAU , Maria WEHBE
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
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Patent Agency Ranking
公开(公告)号：US20210403574A1
公开(公告)日：2021-12-30
申请号：US17471744
申请日：2021-09-10
Applicant: Invectys SA
Inventor： Maria LOUSTAU , François ANNA , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
IPC: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G β2M-free or β2M-associated immunosuppressive isoforms respectively.
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公开(公告)号：US20220056140A1
公开(公告)日：2022-02-24
申请号：US17466607
申请日：2021-09-03
Applicant: Invectys SA
Inventor： Pierre LANGLADE DEMOYEN , Thierry HUET , Julien CAUMARTIN , Maria LOUSTAU , Maria WEHBE
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
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公开(公告)号：US20210325372A1
公开(公告)日：2021-10-21
申请号：US17271767
申请日：2019-08-30
Applicant: INVECTYS SA
Inventor： Maria LOUSTAU , François ANNA , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
Abstract: The present invention relates a method for assessing the functionality of a chimeric antigen receptors (CAR) expressing cell. More specifically, this method is based on a trogocytosis process which involves membrane transfer between antigen expressing target cells and antigen specific immune cells.
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公开(公告)号：US20210309748A1
公开(公告)日：2021-10-07
申请号：US17212165
申请日：2021-03-25
Applicant: Invectys SA
Inventor： Pierre LANGLADE DEMOYEN , Thierry HUET , Julien CAUMARTIN , Maria LOUSTAU , Maria WEHBE
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
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公开(公告)号：US20210254098A1
公开(公告)日：2021-08-19
申请号：US17241546
申请日：2021-04-27
Applicant: Invectys SA
Inventor： Pierre LANGLADE DEMOYEN , Thierry HUET , Simon WAIN-HOBSON , Anna KOSTRZAK
Abstract: The present invention relates to DNA expression vector or a mixture of DNA expression vectors which encodes at least two CD4 epitopes of telomerase reverse transcriptase (TERT) and at least one tumor, viral, bacterial, or parasitic CD8 epitope.
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