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公开(公告)号:US20210040217A1
公开(公告)日:2021-02-11
申请号:US17077502
申请日:2020-10-22
Applicant: Invectys SA
Inventor: Maria LOUSTAU , Anna FRANCOIS , Pierre LANGLADE DEMOYEN , Julien CAUMARTIN
IPC: C07K16/28 , C07K14/705 , C07K14/725 , C12N5/0783
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G β2M-free or β2M-associated immunosuppressive isoforms respectively.