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公开(公告)号：US10052337B2
公开(公告)日：2018-08-21
申请号：US15139138
申请日：2016-04-26
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
CPC分类号： A61K31/575 , A61K9/14 , A61K9/1617 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K45/06 , A61K47/50 , C07J9/005 , A61K2300/00
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US10751349B2
公开(公告)日：2020-08-25
申请号：US16248512
申请日：2019-01-15
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US10646499B2
公开(公告)日：2020-05-12
申请号：US16030141
申请日：2018-07-09
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US20200046736A1
公开(公告)日：2020-02-13
申请号：US16596741
申请日：2019-10-08
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US20190076446A1
公开(公告)日：2019-03-14
申请号：US16030141
申请日：2018-07-09
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US20170035784A1
公开(公告)日：2017-02-09
申请号：US15139138
申请日：2016-04-26
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
IPC分类号： A61K31/575 , A61K45/06 , A61K9/20
CPC分类号： A61K31/575 , A61K9/14 , A61K9/1617 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K45/06 , A61K47/50 , C07J9/005
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
摘要翻译： 本公开涉及具有改善的稳定性，溶解度和/或溶解度的制剂，其制备方法及其治疗各种疾病和病症的方法。
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公开(公告)号：US10758549B2
公开(公告)日：2020-09-01
申请号：US16787796
申请日：2020-02-11
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US20200046735A1
公开(公告)日：2020-02-13
申请号：US16596216
申请日：2019-10-08
发明人： Richard Gail Lancaster , Kay K. Olmstead , Masashi Kagihiro , Mitsuhiro Matono , Ikuko Taoka , Mark Pruzanski , David Shapiro , Roya Hooshmand-Rad , Richard Pencek , Cathi Sciacca , Lise Eliot , Jeffrey Edwards , Leigh A. MacConell , Tonya K. Marmon
摘要： The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
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公开(公告)号：US11413295B2
公开(公告)日：2022-08-16
申请号：US16089477
申请日：2017-03-30
发明人： Mitsuhiro Matono , Tetsuya Hayama
IPC分类号： A61K31/575 , A61K47/26 , A61K47/32 , A61K47/38 , A61K9/20 , A61K47/10 , A61K47/36 , A61K9/28 , A61K9/14 , A61K9/16
摘要： The present invention pertains to an oral preparation having exceptional elutability, the oral preparation containing obeticholic acid or a pharmacologically acceptable salt thereof, a water-soluble excipient, a disintegrating agent, and a water-soluble polymer binder, wherein the oral preparation is a quick-release tablet.
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公开(公告)号：US11331273B2
公开(公告)日：2022-05-17
申请号：US16089544
申请日：2017-03-30
发明人： Mitsuhiro Matono , Tetsuya Hayama
IPC分类号： A61K9/28 , A61K31/575
摘要： The present invention relates to a film-coated tablet having a high chemical stability of an active ingredient, said film-coated tablet comprising: (a) a tablet core containing obeticholic acid or a pharmaceutically acceptable salt thereof; and (b) a coating layer, which is provided on the surface of the tablet core, containing a film base and being substantially free from any plasticizer or containing at least one kind of specific plasticizer.
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