公开(公告)号：US09844583B2

公开(公告)日：2017-12-19

申请号：US14884827

申请日：2015-10-16

Applicant: Indiana University Research & Technology Corporation

Inventor： Ching-Pin Chang

IPC: A01K67/00 ,  C07H21/04 ,  A61K31/70 ,  A61K38/43 ,  A61K9/00 ,  C07K14/47 ,  C12N9/14 ,  A01K67/027 ,  C07K1/00 ,  A61K48/00

CPC classification number: A61K38/43 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/203 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K9/0019 ,  A61K48/00 ,  C07K14/4716 ,  C12N9/14 ,  C12N2310/14 ,  C12Y306/04

Abstract: Nucleic acids encoding modified myosin heavy-chain-associated RNA transcripts are provided. The modified myosin heavy-chain-associated RNA transcripts belongs to a cluster of long noncoding RNAs (lncRNA) and bind to chromatin remodeler Brg1 to inhibit Brg1's genomic targeting and gene regulation function. The modified myosin heavy-chain-associated RNA transcripts expressed in an individual inhibit Brg1's gene regulation function and protect the heart of the individual from myopathy and failure. One of the modified heavy-chain-associated RNAs is a 400 base pair fragment segmented from a natural 779 base pair sequence of Mhrt (Mhrt779) and has the same cardioprotective effects as the Mhrt779.