公开(公告)号：US10259818B2

公开(公告)日：2019-04-16

申请号：US15902742

申请日：2018-02-22

Applicant: Incyte Corporation ,  Incyte Holding Corporation

Inventor： Andrew P. Combs ,  Richard B. Sparks ,  Thomas P. Maduskuie, Jr.

IPC: A61K31/553 ,  C07D487/04 ,  C07C53/18 ,  A61K31/519

Abstract: The present invention provides bicyclic azaheterocyclobenzylamines of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

公开(公告)号：US20190002470A1

公开(公告)日：2019-01-03

申请号：US15902742

申请日：2018-02-22

Applicant: Incyte Corporation ,  Incyte Holding Corporation

Inventor： Andrew P. Combs ,  Richard B. Sparks ,  Thomas P. Maduskuie, JR.

IPC: C07D487/04 ,  C07C53/18 ,  A61K31/553 ,  A61K31/519

Abstract: The present invention provides bicyclic azaheterocyclobenzylamines of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

公开(公告)号：US20240228498A1

公开(公告)日：2024-07-11

申请号：US18430528

申请日：2024-02-01

Applicant: Incyte Corporation

Inventor： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC: C07D487/04 ,  A61P25/28 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61P25/28 ,  A61P35/00 ,  C07B2200/07 ,  C07B2200/13

Abstract: This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20220251087A1

公开(公告)日：2022-08-11

申请号：US17183253

申请日：2021-02-23

Applicant: Incyte Corporation

Inventor： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20220213107A1

公开(公告)日：2022-07-07

申请号：US17537674

申请日：2021-11-30

Applicant: Incyte Corporation

Inventor： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC: C07D487/04 ,  A61P35/00 ,  A61P25/28

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11207302B2

公开(公告)日：2021-12-28

申请号：US16849610

申请日：2020-04-15

Applicant: Incyte Corporation ,  Incyte Holdings Corporation

Inventor： Andrew P. Combs ,  Eddy W. Yue ,  Richard B. Sparks ,  Wenyu Zhu ,  Jiacheng Zhou ,  Qiyan Lin ,  Lingkai Weng ,  Tai-Yuen Yue ,  Pingli Liu

IPC: A61K31/4245 ,  C07D271/08 ,  A61K39/395 ,  C07D413/12 ,  C07D413/04

Abstract: The present invention is directed to 1, 2, 5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2, 3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1, 2, 5-oxadiazole derivatives.

公开(公告)号：US10975088B2

公开(公告)日：2021-04-13

申请号：US16591017

申请日：2019-10-02

Applicant: Incyte Corporation

Inventor： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC: A61K31/53 ,  C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10919912B2

公开(公告)日：2021-02-16

申请号：US16585568

申请日：2019-09-27

Applicant: Incyte Corporation ,  Incyte Holdings Corporation

Inventor： Andrew P. Combs ,  Richard B. Sparks ,  Thomas P. Maduskuie, Jr. ,  James D. Rodgers

IPC: C07D498/04 ,  C07D498/06 ,  C07D498/16 ,  C07D471/06 ,  A61P35/00 ,  C07D519/00

Abstract: The present invention relates to tricyclic heterocycles of Formula (I): which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

公开(公告)号：US10376513B2

公开(公告)日：2019-08-13

申请号：US16112160

申请日：2018-08-24

Applicant: Incyte Corporation ,  Incyte Holdings Corporation

Inventor： Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Yun-Long Li ,  Song Mei ,  Eddy W. Yue

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

公开(公告)号：US20190119287A1

公开(公告)日：2019-04-25

申请号：US16165390

申请日：2018-10-19

Applicant: Incyte Corporation

Inventor： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue

IPC: C07D487/04 ,  C07D519/00 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07B2200/13 ,  C07D471/04 ,  C07D519/00

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.