公开(公告)号：US11624751B2

公开(公告)日：2023-04-11

申请号：US16823085

申请日：2020-03-18

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Sherry Owens ,  Beth Rumberger ,  Huiqing Liu

IPC: A61K31/519 ,  G01N33/68 ,  A61P17/00

Abstract: Biomarkers are provided that are associated with or predictive of a subject's responsiveness to a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing vitiligo.

公开(公告)号：US11584961B2

公开(公告)日：2023-02-21

申请号：US16369724

申请日：2019-03-29

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Huiqing Liu

IPC: C12Q1/68 ,  C12Q1/686 ,  G16H50/30 ,  G16B40/10 ,  C12Q1/6883

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing an inflammatory skin disease.

公开(公告)号：US20190331697A1

公开(公告)日：2019-10-31

申请号：US16381158

申请日：2019-04-11

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Hao Liu ,  Michael A. Pratta

IPC: G01N33/68 ,  A61P37/06 ,  A61K45/06 ,  A61K31/573 ,  A61K31/519

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing Graft-Versus-Host Disease.

公开(公告)号：US20220175731A1

公开(公告)日：2022-06-09

申请号：US17545377

申请日：2021-12-08

Applicant: Incyte Corporation

Inventor： Paul Smith ,  Kurt Andrew Brown ,  Michael D. Howell ,  Fiona Kuo ,  James Lee ,  Leandro Luiz Dos Santos ,  Beth Rumberger

IPC: A61K31/4155 ,  A61K45/06 ,  A61K31/519 ,  A61P17/00

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

公开(公告)号：US11304949B2

公开(公告)日：2022-04-19

申请号：US16370436

申请日：2019-03-29

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Paul Smith

IPC: A61K31/397 ,  C07D403/00 ,  A61K31/519 ,  A61K31/573 ,  A61K45/06

Abstract: The present application provides methods of treating hidradenitis suppurativa in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound which inhibits JAK1 and/or JAK2, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200348313A1

公开(公告)日：2020-11-05

申请号：US16823085

申请日：2020-03-18

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Sherry Owens ,  Beth Rumberger ,  Huiqing Liu

IPC: G01N33/68 ,  A61K31/519 ,  A61P17/00

Abstract: Biomarkers are provided that are associated with or predictive of a subject's responsiveness to a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing vitiligo.

公开(公告)号：US12203942B2

公开(公告)日：2025-01-21

申请号：US17066150

申请日：2020-10-08

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Sherry Owens ,  Michael A. Pratta

IPC: A61K31/397 ,  A61K31/519 ,  A61K31/573 ,  G01N33/68

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing Graft-Versus-Host Disease.

公开(公告)号：US11957661B2

公开(公告)日：2024-04-16

申请号：US17545377

申请日：2021-12-08

Applicant: Incyte Corporation

Inventor： Paul Smith ,  Kurt Andrew Brown ,  Michael D. Howell ,  Fiona Kuo ,  James Lee ,  Leandro Luiz Dos Santos ,  Beth Rumberger

IPC: A61K31/519 ,  A61K31/4155 ,  A61K45/06 ,  A61P17/00

CPC classification number: A61K31/4155 ,  A61K31/519 ,  A61K45/06 ,  A61P17/00

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

公开(公告)号：US11372003B2

公开(公告)日：2022-06-28

申请号：US16381158

申请日：2019-04-11

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Hao Liu ,  Michael A. Pratta

IPC: A61P37/06 ,  A61K31/519 ,  A61K31/573 ,  A61K45/06 ,  G01N33/68

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing Graft-Versus-Host Disease.

公开(公告)号：US20210123931A1

公开(公告)日：2021-04-29

申请号：US17066272

申请日：2020-10-08

Applicant: Incyte Corporation

Inventor： Michael D. Howell ,  Sherry Owens ,  Michael A. Pratta

IPC: G01N33/68 ,  A61K31/519 ,  A61K31/573

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing Graft-Versus-Host Disease.