-
1.发明申请Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof 审中-公开包含激活或增加TLR2活性的佐剂的脂质体组合物及其用途公开(公告)号：US20140234404A1
公开(公告)日：2014-08-21
申请号：US14347928
申请日：2012-10-05
IPC分类号： A61K39/39 , A61K39/02 , A61K39/145 , A61K39/07
CPC分类号： A61K39/145 , A61K9/127 , A61K39/07 , A61K39/099 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , C12N2760/16134
摘要： The invention provides compositions comprising liposomes, an antigen capable of inducing a humoral immune response, a carrier comprising a continuous phase of a hydrophobic substance, and an adjuvant that activates or increases the activity of TLR2. The invention also provides uses for such compositions in inducing a humoral response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by a humoral immune response.
摘要翻译： 本发明提供了包含脂质体，能够诱导体液免疫应答的抗原的组合物，包含疏水性物质的连续相的载体和激活或增加TLR2活性的佐剂。 本发明还提供了用于诱导体液应答的这些组合物的用途，以及用于治疗由体液免疫应答改善的疾病，病症或疾病的方法。
-
公开(公告)号：US11717563B2
公开(公告)日：2023-08-08
申请号：US16283486
申请日：2019-02-22
发明人： Marc Mansour , Leeladhar Sammatur , Lisa Diana MacDonald , Mohan Karkada , Genevieve Mary Weir , Antar Fuentes-Ortega
IPC分类号： A61K39/00 , A61K9/127 , A61K9/10 , A61K31/7088 , A61K9/107 , A61K47/06 , A61K9/19 , A61K31/785
CPC分类号： A61K39/00 , A61K9/10 , A61K9/107 , A61K9/127 , A61K9/19 , A61K31/785 , A61K47/06 , A61K2039/55555 , A61K2039/55561 , Y02A50/30
摘要： The invention provides a composition comprising: an antigen; liposomes; a polyI:C polynucleotide; and a carrier comprising a continuous phase of a hydrophobic substance. Methods for making and using the compositions are also provided.
-
公开(公告)号：US11260116B2
公开(公告)日：2022-03-01
申请号：US16098042
申请日：2017-05-03
摘要： The present application relates to vaccine compositions comprising an amphipathic compound, a neoantigen and a hydrophobic carrier. Further described are methods and use of the vaccine composition for inducing an antibody immune response and/or a cell-mediated immune response to the neoantigen, as well as methods and uses of the vaccine compositions in the treatment of cancer.
-
公开(公告)号：US11077184B2
公开(公告)日：2021-08-03
申请号：US16139361
申请日：2018-09-24
IPC分类号： A61K39/395 , A61K39/145 , A61K9/127 , A61K39/07 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/00
摘要： The invention provides compositions comprising liposomes, an antigen capable of inducing a humoral immune response, a carrier comprising a continuous phase of a hydrophobic substance, and an adjuvant that activates or increases the activity of TLR2. The invention also provides uses for such compositions in inducing a humoral response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by a humoral immune response.
-
公开(公告)号：US10988500B2
公开(公告)日：2021-04-27
申请号：US16715843
申请日：2019-12-16
发明人： Zi-hua Jiang , Jordan David Lewicky , Genevieve Mary Weir , Rajkannan Rajagopalan , Leeladhar Sammatur , Marianne Michelle Stanford , Marc Mansour
IPC分类号： C07H11/04 , A61K39/39 , A61K39/12 , A61K31/7028 , C07H15/18 , A61K39/00 , A61K31/7088 , C12N7/00
摘要： The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.
-
公开(公告)号：US10105435B2
公开(公告)日：2018-10-23
申请号：US14347928
申请日：2012-10-05
IPC分类号： A61K39/395 , A61K39/145 , A61K39/39 , A61K9/127 , A61K39/07 , A61K39/02 , A61K39/12 , A61K39/00
摘要： The invention provides compositions comprising liposomes, an antigen capable of inducing a humoral immune response, a carrier comprising a continuous phase of a hydrophobic substance, and an adjuvant that activates or increases the activity of TLR2. The invention also provides uses for such compositions in inducing a humoral response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by a humoral immune response.
-
公开(公告)号：US10533033B2
公开(公告)日：2020-01-14
申请号：US15541774
申请日：2015-12-11
发明人： Zi-hua Jiang , Jordan David Lewicky , Genevieve Mary Weir , Rajkannan Rajagopalan , Leeladhar Sammatur , Marianne Michelle Stanford , Marc Mansour
IPC分类号： C07H11/04 , A61K39/39 , A61K31/7028 , C07H15/18 , A61K39/00 , A61K39/12 , A61K31/7088 , C12N7/00
摘要： The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.
-
公开(公告)号：US20180009833A1
公开(公告)日：2018-01-11
申请号：US15541774
申请日：2015-12-11
发明人： Zi-hua Jiang , Jordan David Lewicky , Genevieve Mary Weir , Rajkannan Rajagopalan , Leeladhar Sammatur , Marianne Michelle Stanford , Marc Mansour
CPC分类号： C07H11/04 , A61K31/7028 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/585 , A61K2039/6031 , A61K2039/6037 , A61K2039/605 , C07H15/18 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , Y02A50/412 , A61K2300/00
摘要： The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.
-
公开(公告)号：US11406705B2
公开(公告)日：2022-08-09
申请号：US16336162
申请日：2016-09-27
发明人： Marc Mansour , Frederic Ors , Marianne Stanford , Leeladhar Sammatur , Rajkannan Rajagopalan , Lisa Diana MacDonald
摘要： The present disclosure provides methods, uses and compositions and kits for use in inducing an antibody immune response in a human subject. The methods and uses involve administering parenterally a low dose volume of a composition comprising an antigen comprising a B-cell epitope, an amphipathic compound, and a hydrophobic carrier, wherein the low dose volume of the composition is less than 100 μl and induces an antibody immune response to the B-cell epitope in the human subject.
-
10.发明申请公开(公告)号：US20190142928A1
公开(公告)日：2019-05-16
申请号：US16139361
申请日：2018-09-24
摘要： The invention provides compositions comprising liposomes, an antigen capable of inducing a humoral immune response, a carrier comprising a continuous phase of a hydrophobic substance, and an adjuvant that activates or increases the activity of TLR2. The invention also provides uses for such compositions in inducing a humoral response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by a humoral immune response.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.02 秒)
