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    Stable radioiodine conjugates and methods for their systhesis
    3.
    发明申请
    Stable radioiodine conjugates and methods for their systhesis 审中-公开
    稳定的放射性碘共轭物及其合成方法

    公开(公告)号：US20040096394A1

    公开(公告)日：2004-05-20

    申请号：US10713268

    申请日：2003-11-17

    Applicant: Immunomedics, Inc.

    Inventor： Serengulam V. Govindan

    IPC: C07K016/46 ,  C07K014/47 ,  A61K051/00

    CPC classification number: A61K51/0491 ,  A61K51/10 ,  A61K51/1093 ,  C07H3/04 ,  C07K1/1077 ,  G01N33/543

    Abstract: Methods are described for conjugating radioiodinated peptides to non-metabolizable carbohydrates with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising a carbohydrate-appended peptide are also provided. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

    Abstract translation: 描述了将放射性碘化肽与不可代谢的碳水化合物缀合的方法，其具有改善的缀合物的产率和质量。 还提供了包含碳水化合物附加肽的放射性碘化残留抗体缀合物。 瞬时放射性碘化残留抗体缀合物在体内特别稳定，适用于放射免疫检测和放射免疫治疗。

    Stable radioiodine conjugates and methods of their synthesis
    5.
    发明申请
    Stable radioiodine conjugates and methods of their synthesis 有权
    稳定的放射性碘共轭物及其合成方法

    公开(公告)号：US20040022725A1

    公开(公告)日：2004-02-05

    申请号：US10411370

    申请日：2003-04-11

    Applicant: IMMUNOMEDICS, INC.

    Inventor： Serengulam V. Govindan

    IPC: A61K051/00 ,  C07K016/46

    CPC classification number: A61K51/0491 ,  A61K51/088 ,  A61K51/10 ,  A61K51/1093 ,  C07H3/04 ,  C07K1/1077 ,  G01N33/543

    Abstract: Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable amide bonds are coupled to antibodies. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to antibodies. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to antibodies. In a fourth method, a hydrazide-appended antibody is coupled to a radioiodinated carbohydrate or a thiolated antibody is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated antibody. Radioiodinated residualizing antibody conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

    Abstract translation: 描述了将放射性碘化肽或碳水化合物结构与缀合物的产率和质量提高的蛋白质缀合的方法。 在一种方法中，将特异设计的含有非代谢性酰胺键的放射性碘化双功能肽与抗体偶联。 在第二种方法中，也含有氨基多羧酸盐的放射性碘化的不可代谢的双功能肽与抗体偶联。 在第三种方法中，放射性碘化双官能氨基多羧酸盐与抗体偶联。 在第四种方法中，将酰肼附着的抗体与放射性碘化碳水化合物偶联，或硫醇化的抗体与酰肼附着和放射性碘化碳水化合物偶联。 在第五种方法中，使用monoderivatized氰尿酰氯来缀合硫醇化抗体。 通过这些方法制备的放射性碘化残留抗体缀合物在体内特别稳定，适用于放射免疫检测和放射免疫治疗。

    Stable radioiodine conjugates and methods for their synthesis
    6.
    发明申请
    Stable radioiodine conjugates and methods for their synthesis 失效
    稳定的放射性碘共轭物及其合成方法

    公开(公告)号：US20040086454A1

    公开(公告)日：2004-05-06

    申请号：US10686436

    申请日：2003-10-16

    Applicant: Immunomedics, Inc.

    Inventor： Serengulam V. Govindan ,  Gary L. Griffiths

    IPC: A61K051/00 ,  C07K016/46 ,  C07K005/06

    CPC classification number: A61K51/0491 ,  A61K51/088 ,  A61K51/10 ,  A61K51/1093 ,  C07H3/04 ,  C07K1/1077 ,  G01N33/543

    Abstract: Methods are described for conjugating radioiodinated non-metabolizable peptides to proteins and antibodies with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising any aminopolycarboxylate-appended peptide, or any carbohydrate-appended peptide, are also provided. Additionally, methods are described for conjugating radioiodinated aminopolycarboxylates to proteins and antibodies, as well as for conjugating radioiodinated non-metabolizable carbohydrates to proteins and antibodies by a variety of chemical approaches. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

    Abstract translation: 描述了将放射性碘化的不可代谢的肽与蛋白质和抗体结合的方法，其具有改进的缀合物的产率和质量。 还提供了包含任何氨基多羧酸盐附着肽或任何碳水化合物附加肽的放射性碘化残留抗体缀合物。 另外，描述了将放射性碘化氨基多羧酸盐与蛋白质和抗体结合的方法，以及通过各种化学方法将放射性碘化的不可代谢的碳水化合物与蛋白质和抗体缀合。 瞬时放射性碘化残留抗体缀合物在体内特别稳定，适用于放射免疫检测和放射免疫治疗。

    Stable radioiodine conjugates and methods of their synthesis
    7.
    发明申请
    Stable radioiodine conjugates and methods of their synthesis 审中-公开

    公开(公告)号：US20040018148A1

    公开(公告)日：2004-01-29

    申请号：US10395718

    申请日：2003-03-25

    Applicant: IMMUNOMEDICS, INC.

    Inventor： Serengulam V. Govindan ,  Gary L. Griffiths

    IPC: A61K051/00 ,  C07K016/46

    CPC classification number: A61K51/0491 ,  A61K51/088 ,  A61K51/10 ,  A61K51/1093 ,  C07H3/04 ,  C07K1/1077 ,  G01N33/543

    Abstract: Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable amide bonds are coupled to antibodies. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to antibodies. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to antibodies. In a fourth method, a hydrazide-appended antibody is coupled to a radioiodinated carbohydrate or a thiolated antibody is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated antibody. Radioiodinated residualizing antibody conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

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