公开(公告)号：US20210284716A1

公开(公告)日：2021-09-16

申请号：US16880804

申请日：2020-05-21

Applicant: ImmunityBio, Inc.

Inventor： Kayvan Niazi ,  C. Anders Olson ,  Shiho Tanaka ,  John H. Lee ,  Wendy Higashide ,  Patrick Soon-Shiong

IPC: C07K14/81

Abstract: An ACE2-Fc hybrid construct is used as a therapeutic and/or analytic entity to treat an individual infected with a coronavirus or to detect a coronavirus in an analyte. In selected embodiments, the Fc portion of the hybrid construct is an IgA Fc portion, and in still further embodiments the ACE2 portion has a mutation that reduces or abolishes ACE2 catalytic activity.

公开(公告)号：US20210284713A1

公开(公告)日：2021-09-16

申请号：US17082994

申请日：2020-10-28

Applicant: ImmunityBio, Inc.

Inventor： Kayvan Niazi ,  Jay Gardner Nelson ,  Annie Shin ,  Clifford Anders Olson ,  Shiho Tanaka

IPC: C07K14/705 ,  C07K14/005 ,  C12N15/86 ,  A61K39/215

Abstract: Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises a recombinant entity. The recombinant entity comprises a nucleic acid that encodes a extracellular portion of CD40 ligand (CD40L) coupled by a flexible linker to a coronavirus 2 (CoV2) spike protein and/or a CoV2 nucleocapsid protein.

公开(公告)号：US20240327484A1

公开(公告)日：2024-10-03

申请号：US18607825

申请日：2024-03-18

Applicant: ImmunityBio, Inc.

Inventor： Shiho Tanaka ,  Clifford Anders Olson ,  Wendy Higashide ,  Manju Saxena

IPC: C07K14/54 ,  C07K14/715 ,  C12N5/0783

CPC classification number: C07K14/5443 ,  C07K14/5434 ,  C07K14/7155 ,  C12N5/0646 ,  C07K2319/30 ,  C12N2501/2315 ,  C12N2501/39

Abstract: Provided herein are novel soluble-fusion protein complexes comprising interleukin 18 (IL-18) and interleukin 12 (IL-12) polypeptide domains. Also provided are compositions comprising the soluble-fusion protein complexes as well as methods of using the soluble-fusion protein complexes.

公开(公告)号：US20240029820A1

公开(公告)日：2024-01-25

申请号：US18225098

申请日：2023-07-21

Applicant: Nant Holdings IP, LLC ,  ImmunityBio, Inc.

Inventor： Bing Song ,  Shiho Tanaka ,  Clifford Anders Olson ,  Phillip Yang ,  Patrick Soon-Shiong

IPC: G16B15/30 ,  G16B15/20

CPC classification number: G16B15/30 ,  G16B15/20

Abstract: Techniques are provided for computing affinity for protein-protein interaction. 3D structure models of the first and second protein parts are generated using a trained first deep learning model. A 3D structure model of a protein-protein complex comprising the first and the second protein parts is generated using a trained second deep learning model. A low energy score state is determined for the 3D structure models of each of the first and second protein parts, and the protein-protein complex. A relax algorithm applied to amino acid side chain and backbone 3D structure models determines a low energy score state for the 3D structure models. Based on the low energy score states, an energy score is generated for the 3D structure models, and a score difference is determined between the energy scores, where the score difference defines a binding affinity score.