公开(公告)号：US20030206900A1

公开(公告)日：2003-11-06

申请号：US10460471

申请日：2003-06-13

Applicant: INSTITUT PASTEUR ,  Universite Pierre et Marie Curie

Inventor： Therese Ternynck ,  Alexandre Avrameas ,  Gerard Buttin ,  Stratis Avrameas ,  Marie-Francoise Saron ,  Bruno Blondel ,  Therese Couderc ,  Susan Michelson ,  Donato Zipeto

IPC: A61K039/395 ,  C07K016/44 ,  C12P021/02 ,  C12N005/06 ,  C12N015/85

CPC classification number: C07K16/1072 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6883 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K2317/565 ,  C07K2317/80 ,  C07K2319/00 ,  C12N2710/16111 ,  C12N2710/16611 ,  C12N2770/32611 ,  Y02A50/466

Abstract: The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.

公开(公告)号：US20040259822A1

公开(公告)日：2004-12-23

申请号：US10465654

申请日：2003-06-20

Applicant: INSTITUT PASTEUR ,  Universite Pierre et Marie Curie

Inventor： Stratis Avrameas ,  Gerard Buttin ,  Therese Ternynck ,  Faridabano Nato ,  Alexandre Avrameas

IPC: A61K048/00 ,  C07K016/46

CPC classification number: C07K16/18 ,  A61K47/6845 ,  A61K48/00

Abstract: A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.

Abstract translation: 用于将生物活性原理与免疫移动体偶联的产物，其特征在于所述免疫移动体能够使所述生物活性原理内化为真核细胞，并且所述免疫移动体对细胞DNA具有亲和力， 可以将生物活性原子转移到细胞核附近或附近。