公开(公告)号：US20180106772A1

公开(公告)日：2018-04-19

申请号：US15296646

申请日：2016-10-18

Applicant: INSTITUT NATIONAL D'OPTIQUE

Inventor： Serge CARON ,  Sébastien DUBUS ,  Christophe RIVIÈRE ,  Simon TURBIDE ,  Patrick PARADIS

IPC: G01N31/22 ,  B01L3/00 ,  G01N21/77

CPC classification number: G01N31/22 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2400/082 ,  G01N21/65 ,  G01N21/77 ,  G01N21/78 ,  G01N35/08 ,  G01N2021/7733 ,  G01N2021/7763 ,  G01N2021/7786

Abstract: Methods and systems are for determining the concentration of a chemical species in an analyte solution. At least one train of segments are injected into a microfluidic channel having a first end and a second end, each train of segments having segments of analyte solution and segments of sensing solution which are immiscible with the segments of analyte solution. The train of segments is circulated from the first end to the second end of the microfluidic channel such that a reversible chemical exchange is established between the chemical species of each segment of analyte solution and a chemical indicator of the at least one contacting segment of sensing solution. The response of the chemical indicator is measured at the second end of the microfluidic channel and the concentration of the chemical species in the analyte solution is determined based on the response.