公开(公告)号：US20180344850A1

公开(公告)日：2018-12-06

申请号：US15992852

申请日：2018-05-30

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Frederic A. BOURKE, JR. ,  Mark DEWHIRST ,  Neil SPECTOR ,  Paul YOON ,  Justus ADAMSON ,  David ALCORTA ,  Kim LYERLY ,  Leihua LIU ,  Takuya OSADA ,  Mark OLDHAM ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Harold WALDER

IPC分类号： A61K41/00 ,  A61K31/37 ,  A61K45/06 ,  A61K9/00

摘要： A system (and associated method) for treating a human or animal body. The system has a photoactivatable drug for treating a first diseased site, a first pharmaceutically acceptable carrier including one or more phosphorescent or fluorescent agents which are capable of emitting an activation energy into the body which activates the photoactivatable drug, a first device which infuses the first diseased site with a photoactivatable drug and the first pharmaceutically acceptable carrier, a first energy source which irradiates the diseased site with an initiation energy to thereby initiate emission of the activation energy into the body, and a supplemental treatment device which administers one or both of a therapeutic drug or radiation to the body at a second diseased site or the first diseased site, to provide an immune system stimulation in the body.

公开(公告)号：US20220315809A1

公开(公告)日：2022-10-06

申请号：US17433734

申请日：2020-02-27

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： C09J133/08

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.

公开(公告)号：US20220146076A1

公开(公告)日：2022-05-12

申请号：US17433827

申请日：2020-02-27

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Daniel I. BECKER ,  Joseph H. SIMMONS

IPC分类号： F21V9/30 ,  H01L31/06 ,  H01L31/0352 ,  F21S11/00 ,  F21V9/40

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, especially in the field of solar cells and other energy conversion devices.

公开(公告)号：US20220134131A1

公开(公告)日：2022-05-05

申请号：US17433911

申请日：2020-02-28

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： A61N5/06 ,  A61K41/00

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields.

公开(公告)号：US20220193441A1

公开(公告)日：2022-06-23

申请号：US17433850

申请日：2020-02-06

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： A61N5/067

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including photobiomodulation for treatment of conditions, disorders, or diseases.

公开(公告)号：US20220080045A1

公开(公告)日：2022-03-17

申请号：US17538770

申请日：2021-11-30

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Harold WALDER ,  Frederic A. BOURKE, JR. ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Mark OLDHAM ,  Justus ADAMSON ,  Michael NOLAN

IPC分类号： A61K41/00 ,  A61K31/37 ,  A61N5/06 ,  A61N5/10

摘要： A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2: Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2: Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.

公开(公告)号：US20240342287A1

公开(公告)日：2024-10-17

申请号：US18751743

申请日：2024-06-24

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Harold WALDER ,  Frederic A. BOURKE, JR. ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Mark OLDHAM ,  Justus ADAMSON ,  Michael NOLAN

IPC分类号： A61K41/00 ,  A61K31/37 ,  A61K45/06 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61K41/0066 ,  A61K31/37 ,  A61N5/062 ,  A61N5/10 ,  A61K45/06 ,  A61N2005/0661 ,  A61N2005/1098

摘要： A kit for use in performing a cancer treatment, having a vial containing a phosphor-containing drug activator, wherein the phosphor-containing drug activator is present in the vial at a dosage level that is correlated with a size of tumor to be treated, and a container containing the vial;



wherein the phosphor-containing drug activator contains an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; where the two or more phosphors include Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating and a diamond-like carbon coating.

公开(公告)号：US20220275914A1

公开(公告)日：2022-09-01

申请号：US17433748

申请日：2020-01-30

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： F21K2/00

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, such as color enhancement, and color enhancement structures containing the same.

公开(公告)号：US20220184211A1

公开(公告)日：2022-06-16

申请号：US17433890

申请日：2020-01-30

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： A61K41/00 ,  A61N5/06 ,  A61K35/12 ,  C09K11/02 ,  C09K11/77 ,  C09K11/59 ,  C09K11/76 ,  C12N15/01

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, particularly medical uses for treatment of cell proliferation disorders.

公开(公告)号：US20220148997A1

公开(公告)日：2022-05-12

申请号：US17433768

申请日：2020-02-27

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, Jr. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC分类号： H01L23/00 ,  C09K11/02 ,  C09J133/08

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.