公开(公告)号：US10202411B2

公开(公告)日：2019-02-12

申请号：US15304506

申请日：2015-04-16

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： David Dukhan ,  Cyril B. Dousson ,  Gilles Gosselin ,  Jean-Laurent Paparin ,  Guillaume Brandt ,  Rachid Rahali ,  Aurelien Salanson ,  François-René Alexandre

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/20 ,  C07H19/10 ,  C07H19/11 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K45/06 ,  A61K31/7064 ,  A61K31/708 ,  A61K31/7052 ,  A61K31/706

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-substituted methyl or alkynyl nucleosides of Formula I: (I); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, PD, RA, RB1, RB2, RC and Z are as defined herein.