公开(公告)号：US20040156825A1

公开(公告)日：2004-08-12

申请号：US10361111

申请日：2003-02-07

申请人： Hybridon, Inc.

发明人： Sudhir Agrawal ,  Ekambar R. Kandimalla ,  Dong Yu ,  Lakshmi Bhagat

IPC分类号： A61K048/00 ,  C07H021/02

CPC分类号： C07H21/02 ,  A61K2039/55561

摘要： The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The invention provides immunostimulatory agents that are less expensive to make than existing immunostimulatory oligonucleotides. The immunostimulatory agents according to the invention can, in preferred embodiments, cause immune stimulation across species lines.

摘要翻译： 本发明涉及免疫系统的调节。 更具体地，本发明涉及通过使用寡核苷酸衍生的化合物调节免疫系统。 本发明提供免疫刺激剂，其比现有免疫刺激性寡核苷酸便宜。 在优选实施方案中，根据本发明的免疫刺激剂可以跨物种系引起免疫刺激。

公开(公告)号：US20040198685A1

公开(公告)日：2004-10-07

申请号：US10757345

申请日：2004-01-14

申请人： Hybridon, Inc.

发明人： Sudhir Agrawal ,  Lakshmi Bhagat ,  Dong Yu ,  Ekambar R. Kandimalla

IPC分类号： A61K048/00 ,  C07H021/04

CPC分类号： C12N15/117 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/111 ,  C12N2310/17 ,  C12N2310/33 ,  C12N2310/3519 ,  C12N2310/51

摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3null ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5null end.

摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫学和免疫刺激性寡核苷酸。 本发明的免疫原和免疫刺激寡核苷酸优选包含新的嘌呤。 根据本发明的免疫反应物还包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫调节寡核苷酸并具有可接近的5'末端 。

公开(公告)号：US20040097719A1

公开(公告)日：2004-05-20

申请号：US10279684

申请日：2002-10-24

申请人： Hybridon, Inc.

发明人： Sudhir Agrawal ,  Ekambar R. Kandimalla ,  Dong Yu ,  Lakshmi Bhagat

IPC分类号： A61K048/00 ,  C07H021/04

CPC分类号： C07H21/04 ,  A61K39/39 ,  A61K2039/55561

摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3null ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5null end.

摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫
性。 本发明的免疫体包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核苷酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5'端。