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公开(公告)号：US20220178817A1
公开(公告)日：2022-06-09
申请号：US17593983
申请日：2020-03-18
Applicant: Hitachi, Ltd.
Inventor： Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Shunsuke KONO , Akihiro NOJIMA
Abstract: An object of the invention is to provide an optical analysis method and an optical analysis system capable of accurately performing an optical analysis by using transmitted light even though a sample contains a turbid substance. The optical analysis method of the present disclosure is an optical analysis method for irradiating a sample s containing a turbid substance in a cell 11 with light and performing optical analysis on the sample s by using transmitted light of the light. The optical analysis method includes: exciting the sample s in the cell 11 by irradiation with ultrasonic waves while adjusting a frequency of the ultrasonic waves such that an intensity of the transmitted light is maximized, and then performing the optical analysis in a state where the sample s is irradiated with ultrasonic waves of this adjusted frequency.
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2.发明申请公开(公告)号：US20200291341A1
公开(公告)日：2020-09-17
申请号：US16774048
申请日：2020-01-28
Applicant: HITACHI, LTD.
Inventor： Shunsuke KONO , Takuya KAMBAYASHI , Toshimitsu NOGUCHI , Akihiro NOJIMA
Abstract: Human labor and time can be reduced, and a high-accuracy numerical model can be created. Provided is a pseudo sample creation method including mixing a pre-culture liquid medium that is not used to culture a sample, a post-culture liquid medium that is used to culture the sample, and an additive containing at least one of saccharides, an amino acid, a metabolite, and protein with one another to create a pseudo sample. In addition, provided is a numerical model creation system including: a spectrometer that acquires spectral data of a pseudo sample; a reference value measuring device that measures a reference value of the pseudo sample; and an analyzer that creates a numerical model representing a correlation between the spectral data and the reference value based on the spectral data and the reference values obtained from a plurality of pseudo samples.
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3.发明申请公开(公告)号：US20200182751A1
公开(公告)日：2020-06-11
申请号：US16707552
申请日：2019-12-09
Applicant: Hitachi, Ltd.
Inventor： Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Akihiro NOJIMA , Shunsuke KONO
Abstract: Please substitute the new Abstract set forth below for the original Abstract: The object of the invention is to perform, rapidly and at a low cost, a pretreatment of an analysis sample containing a turbid substance. Provided is an analysis sample pretreatment apparatus in which a clarified liquid is obtained by removing a turbid substance from an analysis sample. The analysis sample pretreatment apparatus includes a cell configured to store the analysis sample, and a cell holder in which at least a part of a housing is opened to mount the cell. The cell holder includes an ultrasonic wave transducer and an ultrasonic wave reflection plate that are disposed on facing plane pairs while sandwiching the cell mounted inside the cell holder. The cell includes a first opening unit from which the analysis sample flows in, a second opening unit from which the clarified liquid flows out, and a third opening unit from which the turbid substance is discharged. In a state where the cell is mounted in the cell holder, the first opening unit is provided at a position lower than an upper end of the ultrasonic wave transducer in a vertical direction, or at a position higher than a lower end of the ultrasonic wave transducer in the vertical direction.
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公开(公告)号：US20190302006A1
公开(公告)日：2019-10-03
申请号：US16208464
申请日：2018-12-03
Applicant: HITACHI, LTD.
Inventor： Shunsuke KONO , Takuya KAMBAYASHI , Toshimitsu NOGUCHI
Abstract: An analysis system is provided which enables an optical analysis with high accuracy.An analysis system A in which light is radiated on a liquid sample to analyze the sample includes a reaction part 1 which includes a reaction tank 12, an inlet port 14, and an outlet port 16, an analysis part 2 which includes an analysis cell 22a, at least one light source part 24, and at least one light receiving part 26, and a flow path tube 3 which includes a first flow path 32 and a second flow path 34. A measurement part 222 of the analysis cell 22a includes a first measurement portion 2221 and a second measurement portion 2222, which have mutually different sectional areas.
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Patent Agency Ranking
5.发明申请公开(公告)号：US20180345236A1
公开(公告)日：2018-12-06
申请号：US15869477
申请日：2018-01-12
Applicant: Hitachi, Ltd.
Inventor： Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Shinichi TANIGUCHI
Abstract: A reaction vessel includes a vessel that accommodates a substance, a stirring device that stirs the substance, and a bypass that causes the substance to circulate outside the vessel, in which one end and the other end of the bypass are connected to the vessel in a position at which the substance circulates in the bypass when the substance is stirred by the stirring device.
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公开(公告)号：US20220317023A1
公开(公告)日：2022-10-06
申请号：US17596051
申请日：2020-03-19
Applicant: Hitachi, Ltd.
Inventor： Takuya KAMBAYASHI , Toshimitsu NOGUCHI , Shunsuke KONO , Akihiro NOJIMA
Abstract: An arithmetic expression used for estimating a target item of a specimen is more easily incorporated into an optical measurement system. An optical measurement instrument includes an optical analysis unit configured to perform an optical analysis on a specimen and measure an intensity of light as a result of the optical analysis, and an arithmetic processing unit configured to download an arithmetic expression from a server device via a network, and perform a quantitative analysis on a target substance contained in the specimen by substituting the result of the optical analysis by the optical analysis unit into the arithmetic expression.
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公开(公告)号：US20190302017A1
公开(公告)日：2019-10-03
申请号：US16208432
申请日：2018-12-03
Applicant: HITACHI, LTD.
Inventor： Takuya KAMBAYASHI , Toshimitsu NOGUCHI , Shunsuke KONO
Abstract: To provide a reaction system capable of analyzing a liquid sample with high accuracy. To provide a reaction system A including: a reaction vessel 1, a flow channel 2 including a deformable unit 22 having an elastic member, a pump 3, a flow channel deformation mechanism 4, a measurement unit 5 and an analysis unit 6, wherein the measurement unit 5 includes a light source unit 52 and a light receiving unit 54, the flow channel deformation mechanism 4 includes an operation unit 42 for deforming the deformable unit 22 of the flow channel 2 such that a cross-sectional area of the deformable unit 22 is reduced, and the analysis unit 6 is electrically or physically connected to the measurement unit 5 and the flow channel deformation mechanism 4, and operates the flow channel deformation mechanism 4 based on a measurement result obtained by the measurement unit 5.
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8.发明申请公开(公告)号：US20190299129A1
公开(公告)日：2019-10-03
申请号：US16180433
申请日：2018-11-05
Applicant: HITACHI, LTD.
Inventor： Toshimitsu NOGUCHI , Takuya KAMBAYASHI
Abstract: A turbid matter separating apparatus extracts turbid matter and a supernatant liquid separately from a suspension. The invention is directed to a turbid matter separating apparatus which includes a liquid container which includes a sediment discharge port and a supernatant liquid discharge port and is filled with a suspension containing turbid matter, a sediment valve which is provided in the sediment discharge port, a supernatant liquid valve which is provided in the supernatant liquid discharge port, an ultrasonic irradiator which irradiates the suspension filled in the liquid container with ultrasound, and a control unit which controls the sediment valve, the supernatant liquid valve, and the ultrasonic irradiator, the control unit being configured to control the sediment valve to discharge a sediment and controls a supernatant liquid valve to discharge a supernatant liquid after a predetermined time elapses since the irradiation with ultrasound by the ultrasonic irradiator is stopped.
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9.发明申请公开(公告)号：US20190162654A1
公开(公告)日：2019-05-30
申请号：US15940140
申请日：2018-03-29
Applicant: Hitachi, Ltd.
Inventor： Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Shinichi TANIGUCHI
IPC: G01N21/27
CPC classification number: G01N21/27 , G01N21/85 , G01N2021/8557 , G01N2021/8578
Abstract: To perform more accurate analysis of a composition of a substance given at a sampling time, provided is an optical analysis apparatus, including: a flow passage, which is connected to a vessel, and is configured to allow a first substance to flow therethrough; an introduction unit, which is provided to the flow passage, and is configured to introduce at least two second substances to the flow passage, to thereby divide the first substance flowing through the flow passage; and a measurement unit, which is provided to the flow passage, and is configured to perform measurement by irradiating the first substance and the second substance flowing through the flow passage with light.
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