公开(公告)号：US08497080B2

公开(公告)日：2013-07-30

申请号：US13759765

申请日：2013-02-05

申请人： HistoRx, Inc.

发明人： Mark Gustavson ,  Jennifer Giltnane ,  Marisa P. Dolled-Filhart ,  Robert L. Camp ,  David L. Rimm

IPC分类号： G01N31/00 ,  G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/5035 ,  G01N33/5041 ,  G01N33/5082 ,  G01N33/566 ,  G01N33/574 ,  Y10T436/10

摘要： The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.

摘要翻译： 本发明的方法涉及通过免疫组织化学技术测定组织切片中的信号转导活性。 确定感兴趣受体的表达水平以及受体信号转导途径的一个或多个效应分子的表达水平。 此外，发现亚细胞区室中效应分子与受体表达的表达水平的组合比具有预后意义。

公开(公告)号：US20130143763A1

公开(公告)日：2013-06-06

申请号：US13759765

申请日：2013-02-05

申请人： HistoRx, Inc. ,  Yale University

发明人： Mark Gustavson ,  Jennifer Giltnane ,  Marisa P. Dolled-Filhart ,  Robert L. Camp ,  David L. Rimm

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5035 ,  G01N33/5041 ,  G01N33/5082 ,  G01N33/566 ,  G01N33/574 ,  Y10T436/10

摘要： The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.

摘要翻译： 本发明的方法涉及通过免疫组织化学技术测定组织切片中的信号转导活性。 确定感兴趣受体的表达水平以及受体信号转导途径的一个或多个效应分子的表达水平。 此外，发现亚细胞区室中效应分子与受体表达的表达水平的组合比具有预后意义。