公开(公告)号：US4038287A

公开(公告)日：1977-07-26

申请号：US676134

申请日：1976-04-12

申请人： Hirohide Takayama ,  Kiyoshi Niino ,  Sigeo Fukuda

发明人： Hirohide Takayama ,  Kiyoshi Niino ,  Sigeo Fukuda

IPC分类号： C07D233/48 ,  C07D233/88

CPC分类号： C07D233/48

摘要： Compounds of allantoin with basic amino acids have a solubility which is from about 25 to 50 times greater than that of pure allantoin. The compounds have almost the same pharmacological effects as allantoin and the basic amino acids and they are harmless. The compounds can be used in medicines, cosmetics, creams and ointments.

公开(公告)号：US4025525A

公开(公告)日：1977-05-24

申请号：US613913

申请日：1975-09-16

申请人： Hirohide Takayama ,  Ippei Yoshimura

发明人： Hirohide Takayama ,  Ippei Yoshimura

IPC分类号： A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  C07D207/28 ,  C07D233/88 ,  C07D403/02 ,  C07F5/06

CPC分类号： C07D233/88 ,  C07D207/28

摘要： Allantoin compound with a metal salt of 2-pyrrolidone-5-carboxylic acid has a solubility which is from 2.5 to 4 times greater than that of pure allantoin. The compound has almost the same pharmacological effect as allantoin itself and is harmless, and therefore it can be used in medicines, cosmetics, creams, ointments, etc.

摘要翻译： 具有2-吡咯烷酮-5-羧酸的金属盐的尿囊素化合物的溶解度比纯尿囊素的溶解度高2.5至4倍。 该化合物与尿囊素本身具有几乎相同的药理作用，无害，因此可用于药物，化妆品，霜剂，软膏等。