公开(公告)号：US20240019444A1

公开(公告)日：2024-01-18

申请号：US18470273

申请日：2023-09-19

申请人： HiberCell, Inc.

发明人： Nandita Bose ,  Nadine Ottoson ,  Ben Harrison ,  Jamie Lowe ,  Mark Uhlik ,  Jeremy Graff ,  Richard Huhn

IPC分类号： G01N33/68 ,  A61K31/716

CPC分类号： G01N33/6854 ,  A61K31/716 ,  G01N2400/24 ,  G01N2800/52

摘要： This disclosure provides, in one aspect, dosing strategies for soluble β-glucan immunotherapy to optimize acute immunopharmacodynamic responses for the immunotherapy and/or subject. It also provides a method for analyzing a sample from a subject for a biomarker to identify the appropriate dosing strategy for soluble β-glucan immunotherapy. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-β-glucan antibody level or immunopharmacodynamic response level, classifying the subject into a subgroup based on the biomarker anti-β-glucan antibody level or immunopharmacodynamic response level and identifying the appropriate dosing strategy based on the subgroup classification.

公开(公告)号：US11815435B2

公开(公告)日：2023-11-14

申请号：US16488911

申请日：2018-02-23

申请人： HiberCell, Inc.

发明人： Nandita Bose ,  Nadine Ottoson ,  Ben Harrison ,  Jamie Lowe ,  Mark Uhlik ,  Jeremy Graff ,  Richard Huhn

IPC分类号： G01N33/68 ,  A61K31/716

CPC分类号： G01N33/6854 ,  A61K31/716 ,  G01N2400/24 ,  G01N2800/52

摘要： This disclosure provides, in one aspect, dosing strategies for soluble β-glucan immunotherapy to optimize acute immunopharmacodynamic responses for the immunotherapy and/or subject. It also provides a method for analyzing a sample from a subject for a biomarker to identify the appropriate dosing strategy for soluble β-glucan immunotherapy. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-β-glucan antibody level or immunopharmacodynamic response level, classifying the subject into a subgroup based on the biomarker anti-β-glucan antibody level or immunopharmacodynamic response level and identifying the appropriate dosing strategy based on the subgroup classification.