公开(公告)号：US08736837B2

公开(公告)日：2014-05-27

申请号：US13968744

申请日：2013-08-16

申请人： Handyem inc.

发明人： Dany Nolet ,  Alain Chandonnet ,  Michel Fortin

IPC分类号： G01N21/00

CPC分类号： G01N15/1436 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1006

摘要： The present disclosure relates to the field characterization of particles in a sample solution. More specifically, the present disclosure relates to a flow cell and a method for characterizing particles by means of collected non-Gaussian temporal signals. The present flow cell and method rely on an excitation fiber with a channel. The excitation fiber has a core for transporting an excitation light generated by a light source, and defines a channel through a portion of its core. The channel of the excitation fiber directs a flow of the sample solution. The excitation fiber, the channel and collection fibers characteristics are selected, proportioned and positioned to generate collected light with a non-Gaussian temporal intensity profile.

摘要翻译： 本公开涉及样品溶液中颗粒的场表征。 更具体地，本公开涉及通过收集的非高斯时间信号来表征粒子的流动池和方法。 本流动池和方法依赖于具有通道的激发光纤。 激发光纤具有用于传输由光源产生的激发光的芯，并且通过其芯的一部分限定通道。 激发光纤的通道引导样品溶液的流动。 激发光纤，通道和收集光纤特性被选择，成比例和定位，以产生具有非高斯时间强度分布的收集光。

公开(公告)号：US10359354B2

公开(公告)日：2019-07-23

申请号：US15106056

申请日：2013-12-18

申请人： HANDYEM INC.

发明人： Michel Fortin ,  Alain Chandonnet ,  Dany Nolet

IPC分类号： G01N15/14 ,  G01N21/64 ,  G01N21/05 ,  G01N21/53 ,  G01N21/47 ,  G01N15/10

摘要： The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.

公开(公告)号：US20130342837A1

公开(公告)日：2013-12-26

申请号：US13968744

申请日：2013-08-16

申请人： Handyem inc.

发明人： Alain Chandonnet ,  Michel Fortin ,  Dany Nolet

IPC分类号： G01N15/14

CPC分类号： G01N15/1436 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1006

摘要： The present disclosure relates to the field characterization of particles in a sample solution. More specifically, the present disclosure relates to a flow cell and a method for characterizing particles by means of collected non-Gaussian temporal signals. The present flow cell and method rely on an excitation fiber with a channel. The excitation fiber has a core for transporting an excitation light generated by a light source, and defines a channel through a portion of its core. The channel of the excitation fiber directs a flow of the sample solution. The excitation fiber, the channel and collection fibers characteristics are selected, proportioned and positioned to generate collected light with a non-Gaussian temporal intensity profile.

摘要翻译： 本公开涉及样品溶液中颗粒的场表征。 更具体地，本公开涉及通过收集的非高斯时间信号来表征粒子的流动池和方法。 本流动池和方法依赖于具有通道的激发光纤。 激发光纤具有用于传输由光源产生的激发光的芯，并且通过其芯的一部分限定通道。 激发光纤的通道引导样品溶液的流动。 激发光纤，通道和收集光纤特性被选择，成比例和定位，以产生具有非高斯时间强度分布的收集光。