公开(公告)号：US20100029559A1

公开(公告)日：2010-02-04

申请号：US12380760

申请日：2009-03-02

Applicant: Haesun KIM ,  Anthony O. CAGGIANO

Inventor： Haesun KIM ,  Anthony O. CAGGIANO

IPC: A61K38/18 ,  C12Q1/68 ,  A61P25/00

CPC classification number: A61K38/1883 ,  A61K38/18 ,  A61K45/06 ,  G01N33/6872 ,  G01N33/6896 ,  G01N2333/4756 ,  G01N2800/285 ,  A61K2300/00

Abstract: The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient. In a particular embodiment, the patient is suffering from a disease or disorder associated with reduced levels of myelination and the GGF2 is administered to promote myelination in the patient.

Abstract translation: 本发明涉及向有需要的患者施用胶质细胞生长因子2（GGF2），以在基于患有病症的疾病或病症确定的期望治疗窗口内实现GGF2的血清水平。 在一个具体实施方案中，患者患有与减少的髓鞘形成水平相关的疾病或病症，并且施用GGF2以促进患者的髓鞘形成。

公开(公告)号：US20110014158A1

公开(公告)日：2011-01-20

申请号：US12781762

申请日：2010-05-17

Applicant: Anthony O. CAGGIANO ,  Andrea VECCHIONE ,  Jennifer IACI

Inventor： Anthony O. CAGGIANO ,  Andrea VECCHIONE ,  Jennifer IACI

IPC: A61K38/51 ,  C12N9/88 ,  A61K35/12 ,  A61P29/00 ,  A61P25/00 ,  A61M37/00

CPC classification number: A61K38/51 ,  A61K38/00 ,  C12N9/88 ,  C12Y402/0202 ,  C12Y402/02021

Abstract: The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

Abstract translation: 本发明涉及软骨素酶ABCI的蛋白质和核酸突变体。 这种软骨素酶ABCI突变体酶表现出改变的软骨素裂解酶活性或增强的对包括UV光或热量在内的应激物灭活的抗性。 还提供了使用软骨素酶ABCI突变酶的方法。

公开(公告)号：US20100239557A1

公开(公告)日：2010-09-23

申请号：US12757006

申请日：2010-06-04

Applicant: Anthony O. CAGGIANO ,  Jennifer IACI ,  Andrea VECCHIONE ,  Elizabeth MARKENSOHN

Inventor： Anthony O. CAGGIANO ,  Jennifer IACI ,  Andrea VECCHIONE ,  Elizabeth MARKENSOHN

IPC: A61K38/51 ,  C12N9/88 ,  A61P25/00

CPC classification number: C12N9/88 ,  A61K38/00 ,  A61K38/51 ,  C12Y402/02004

Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

Abstract translation: 本发明的一个方面涉及软骨素酶ABCI的突变体。 这种软骨素酶ABCI突变体表现出改变的软骨素裂解酶活性或增加的抗应激因子灭活活性，包括暴露于紫外光或热。 还提供了使用软骨素酶ABCI突变酶的方法。

公开(公告)号：US20120308547A1

公开(公告)日：2012-12-06

申请号：US13543749

申请日：2012-07-06

Applicant: Anthony O. CAGGIANO ,  Jennifer IACI ,  Andrea VECCHIONE ,  Elizabeth MARKENSOHN

Inventor： Anthony O. CAGGIANO ,  Jennifer IACI ,  Andrea VECCHIONE ,  Elizabeth MARKENSOHN

IPC: A61K38/51 ,  A61P25/00 ,  C12N9/88

CPC classification number: C12N9/88 ,  A61K38/00 ,  A61K38/51 ,  C12Y402/02004

Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

Abstract translation: 本发明的一个方面涉及软骨素酶ABCI的突变体。 这种软骨素酶ABCI突变体表现出改变的软骨素裂解酶活性或增加的抗应激因子灭活活性，包括暴露于紫外光或热。 还提供了使用软骨素酶ABCI突变酶的方法。

公开(公告)号：US20110262413A1

公开(公告)日：2011-10-27

申请号：US13103347

申请日：2011-05-09

Applicant: Elliott A. GRUSKIN ,  Jack L. TSENG ,  Anthony O. CAGGIANO

Inventor： Elliott A. GRUSKIN ,  Jack L. TSENG ,  Anthony O. CAGGIANO

IPC: A61K35/14 ,  A61P29/00

CPC classification number: A61K38/51 ,  A61K38/47

Abstract: A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.

Abstract translation: 提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。 已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。 本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。 还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。 还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。