公开(公告)号：US20180251441A1

公开(公告)日：2018-09-06

申请号：US15756788

申请日：2016-09-01

申请人： HOWARD HUGHES MEDICAL INSTITUTE

发明人： Luke D. LAVIS ,  Jonathan B. GRIMM ,  Laurel M. HECKMAN ,  Eric R. SCHREITER

IPC分类号： C07D311/16 ,  C09K11/06 ,  C07D311/82 ,  C07D405/12 ,  C07D307/94 ,  A61K41/00 ,  A61N5/06 ,  G01N21/64

CPC分类号： C07D311/16 ,  A61K41/0057 ,  A61N5/06 ,  A61N5/062 ,  C07D307/94 ,  C07D311/82 ,  C07D405/12 ,  C09K11/06 ,  C09K2211/1022 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6439

摘要： The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.