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公开(公告)号：US20160002338A1
公开(公告)日：2016-01-07
申请号：US14710194
申请日：2015-05-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , Richard Buick , Michael Gerg , Frank Kroner , Gerhard Niederfellner , Carmen Peess , Michael Schraeml
CPC classification number: C07K16/2863 , A61K47/6871 , A61K2039/505 , A61K2039/6068 , C07K16/32 , C07K16/34 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: The invention relates to specific anti-HER3 antibodies, that bind to the beta-hairpin of HER3, their preparation and use as medicament.
Abstract translation: 本发明涉及结合HER3的β-发夹的特异性抗HER3抗体，其制备和用作药物。
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公开(公告)号：US20140186358A1
公开(公告)日：2014-07-03
申请号：US14073149
申请日：2013-11-06
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
Abstract: The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
Abstract translation: 本发明涉及抗HER3抗原结合蛋白，例如， 抗HER3抗体，其结合HER3的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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3.发明申请ANTI-HER3/HER4 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3 AND THE BETA-HAIRPIN OF HER4 有权抗HER3 / HER4抗体与HER3的BETA-HAIRPIN和HER4的BETA-HAIRPIN结合公开(公告)号：US20140186354A1
公开(公告)日：2014-07-03
申请号：US14073137
申请日：2013-11-06
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
Abstract: The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
Abstract translation: 本发明涉及抗HER3 / HER4抗原结合蛋白，例如 抗HER3 / HER4抗体，其结合HER3的β发夹和HER4的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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4.发明申请POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY 审中-公开聚多肽 - 多核苷酸复合物及其在目标效应器运输中的应用公开(公告)号：US20130344094A1
公开(公告)日：2013-12-26
申请号：US13924233
申请日：2013-06-21
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Michael Gerg , Dieter Heindl , Gerhard Niederfellner , Wolfgang Schaefer , Michael Schraeml , Michael Tacke
IPC: C07K16/46
CPC classification number: C07K16/46 , A61K47/6889 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/92 , G01N33/573 , G01N33/6863
Abstract: Herein is reported a polypeptide-polynucleotide-complex as therapeutic agent and its use as tool for the targeted delivery of an effector moiety. The polynucleotide part of the complex is essentially resistant to proteolytic and enzymatic degradation in vivo. Additionally the polypeptide part specifically binds to a compound or structure such as a tissue or organ, a process or a disease. Thus, one aspect as reported herein is a polypeptide-polynucleotide-complex comprising a) a polypeptide specifically binding to a target and conjugated to a first member of a binding pair, b) a polynucleotide linker conjugated at its first terminus to the second member of the binding pair, and c) an effector moiety conjugated to a polynucleotide that is complementary to at least a part of the polynucleotide linker.
Abstract translation: 本文报道了作为治疗剂的多肽 - 多核苷酸复合物及其作为靶向递送效应子部分的工具的用途。 复合物的多核苷酸部分在体内基本上抗蛋白水解和酶降解。 另外，多肽部分特异性结合化合物或结构如组织或器官，过程或疾病。 因此，本文报道的一个方面是多肽 - 多核苷酸复合物，其包含a）特异性结合靶并与结合对的第一个成员缀合的多肽，b）在其第一个末端缀合至第二个成员 所述结合对，和c）与多核苷酸缀合的效应部分，其与所述多核苷酸接头的至少一部分互补。
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公开(公告)号：US09783611B2
公开(公告)日：2017-10-10
申请号：US14710194
申请日：2015-05-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , Richard Buick , Michael Gerg , Frank Kroner , Gerhard Niederfellner , Carmen Peess , Michael Schraeml
CPC classification number: C07K16/2863 , A61K47/6871 , A61K2039/505 , A61K2039/6068 , C07K16/32 , C07K16/34 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: The invention relates to specific anti-HER3 antibodies, that bind to the beta-hairpin of HER3, their preparation and use as medicament.
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Patent Agency Ranking
公开(公告)号：US09725512B2
公开(公告)日：2017-08-08
申请号：US14073149
申请日：2013-11-06
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC: A61K39/395 , C07K16/28 , C07K16/32 , C07K14/195 , A61K47/48 , C07K14/71
CPC classification number: C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
Abstract: The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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7.发明授权公开(公告)号：US09725511B2
公开(公告)日：2017-08-08
申请号：US14073137
申请日：2013-11-06
Applicant: Hoffmann-La Roche Inc.
Inventor： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC: A61K39/395 , C07K16/28 , C07K16/32 , A61K47/48 , A61K39/00
CPC classification number: C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
Abstract: The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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公开(公告)号：US20160138004A1
公开(公告)日：2016-05-19
申请号：US14877475
申请日：2015-10-07
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC: C12N9/90 , G01N33/573 , C07K14/65 , C07K14/475 , C07K16/40 , C07K16/22
CPC classification number: C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
Abstract: Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
Abstract translation: 本文报道了根据式I的融合多肽，NH2-S2-X1-S1-COOH（式I），其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠 衍生自第二多肽的氨基酸序列和 - 表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1 被插入代替第二多肽的插入片段结构域。
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9.发明申请公开(公告)号：US20160002346A1
公开(公告)日：2016-01-07
申请号：US14710198
申请日：2015-05-12
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Birgit Bossenmaier , Michael Gerg , Gerhard Niederfellner , Carmen Peess , Michael Schraeml
CPC classification number: C07K16/3076 , A61K2039/505 , A61K2039/6068 , C07K14/71 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/77 , G01N33/6854
Abstract: The invention relates to anti-HER1 antigen binding proteins, e.g. anti-HER1 antibodies, that bind to the beta-hairpin of HER1, methods for selecting these antigen binding proteins, their preparation and use as medicament.
Abstract translation: 本发明涉及抗HER1抗原结合蛋白，例如， 抗HER1抗体，其结合HER1的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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公开(公告)号：US09938340B2
公开(公告)日：2018-04-10
申请号：US14877475
申请日：2015-10-07
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC: C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
CPC classification number: C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
Abstract: Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
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