公开(公告)号：US10825195B2

公开(公告)日：2020-11-03

申请号：US16091245

申请日：2017-03-02

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Franziska Mech ,  Angelika Fuchs ,  Jan Kuentzer ,  Otto Huber ,  Alex Kohn ,  Eckhart Guthoehrlein

IPC: G06T7/73 ,  G06T7/00 ,  G06T7/50 ,  G06T7/30 ,  G16H30/20 ,  G06F16/51 ,  G06K9/00 ,  G06K9/62 ,  G06T7/60

Abstract: An image analysis method for analyzing an IHC tissue sample includes storing, for each of one or more sets of digital images, a set-ID in a spatial database of a spatial DBMS, the images of each set depicting the same or adjacent layers of the IHC tissue sample; storing, for each of the, a plurality of spatial data objects in the database in association with the set-ID; creating, by the spatial DBMS, at least one spatial index covering the objects of the images contained in the one or more sets; applying, by the spatial DBMS, a spatial database operation on the at least one spatial index for determining the relative positions of objects of two or more images of a selected set; and providing the relative positions as input for determining the distance and/or relative position of the biomedical features of the tissue sample.