公开(公告)号：US11154605B2

公开(公告)日：2021-10-26

申请号：US16620846

申请日：2018-06-07

申请人： HIPRA SCIENTIFIC, S.L.U.

发明人： Xavier Gibert Pérez ,  Marta Sitjà Arnau

IPC分类号： A61K39/08 ,  A61K9/00 ,  A61K39/00

摘要： The present invention relates to an immunogenic composition comprising one or more C. difficile toxoid for use in a medicament for animals. The invention also encompasses an immunogenic composition comprising one or more C. difficile A toxoid and one or more C. difficile B toxoid and one or more C. perfringens Type A toxoid. The invention also encompasses vaccines comprising said immunogenic compositions, vaccines for use in the treatment and/or prevention of disease caused by C. difficile and C. perfringens, and kits thereof.

公开(公告)号：US11332739B2

公开(公告)日：2022-05-17

申请号：US16322316

申请日：2017-07-31

申请人： HIPRA SCIENTIFIC, S.L.U. ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

发明人： Xavier Gibert Pérez ,  Marta Sitjà Arnau ,  Maria Mar Fenech Martínez ,  Santiago Francisco Elena Fito ,  Susana Martín García

IPC分类号： C12N15/10 ,  C12N7/00 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  A61K39/00

摘要： The present invention relates to a method for preparing cDNA infectious clones based on the genome of an attenuated Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and uses thereof for preparing efficacious and safety-enhanced vaccines against PRRSV. The invention further comprises an infectious cDNA clone obtainable by such method. The invention further provides an attenuated modified PRRSV, and immunogenic compositions and vaccines comprising that attenuated PRRSV. The present invention further provides the attenuated PRRSV for use in the prophylaxis and/or the treatment of PRRSV infections, and the attenuated PRRSV for use as vaccine or medicament in the prophylaxis and/or the treatment of PRRSV infections.

公开(公告)号：US11744883B2

公开(公告)日：2023-09-05

申请号：US16955015

申请日：2018-12-19

申请人： HIPRA SCIENTIFIC, S.L.U.

发明人： Jordi Montane Giralt ,  Ester Puigvert Molas ,  Alexandra Moros Sanz ,  Marta Sitjà Arnau

IPC分类号： A61K39/02 ,  A61K39/12 ,  A61P31/20 ,  A61K9/00 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K39/0241 ,  A61K9/0019 ,  A61K39/12 ,  A61K39/39 ,  A61P31/20 ,  A61K2039/521 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70

摘要： The present invention provides a combination vaccine comprising one or more antigens of Mycoplasmahyopneumoniae, one or more antigens of Porcine circovirus, and pharmaceutically acceptable excipients and/or carriers, for use in the prevention and/or treatment of porcine enzootic pneumonia and/or Porcine Circovirus-Associated Diseases (PCVAD) by administration of the vaccine into the dermis of livestock, wherein the one or more antigens of porcine circovirus comprises the PCV2 ORF2 protein in an amount from 0.1 μg/dose to 10 μg/dose.