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    Warming jug
    1.
    发明授权
    Warming jug 失效
    温暖的水罐

    公开(公告)号：US4422442A

    公开(公告)日：1983-12-27

    申请号：US275495

    申请日：1981-06-22

    Applicant: Gutmann Franz ,  Peter Sieber

    Inventor： Gutmann Franz ,  Peter Sieber

    IPC: A47G19/12 ,  A47J27/00

    CPC classification number: A47G19/127 ,  A47G19/12

    Abstract: The warming jug consists of a jacket (1) of several parts and a metal bottom (2). Parts of the jacket (1) are: an upper section (3) with a handle (15), an intermediate ring (5) and a closing ring (7). The metal bottom (2) is arranged in a circular groove (10) between the closing ring (7) and the intermediate ring (5). To ensure tightness, an additional seal (13) is arranged between the border of the bottom (6) and the intermediate ring (5) or the closing ring (7). The jacket parts (3, 5 and 7) are made of synthetic and are bonded together to one unit.

    Abstract translation: 升温壶由几个部分的夹套（1）和金属底部（2）组成。 护套（1）的部分是：具有手柄（15）的上部（3），中间环（5）和闭合环（7）。 金属底部（2）布置在闭合环（7）和中间环（5）之间的圆形槽（10）中。 为了确保密封性，在底部（6）和中间环（5）或闭合环（7）的边界之间设置附加的密封件（13）。 夹套部件（3,5,7）由合成材料制成，并结合在一起。

    Systems and methods of accessing and updating recorded data via an inter-object proxy
    2.
    发明申请
    Systems and methods of accessing and updating recorded data via an inter-object proxy 有权
    通过对象间代理访问和更新记录数据的系统和方法

    公开(公告)号：US20070156690A1

    公开(公告)日：2007-07-05

    申请号：US11322712

    申请日：2005-12-30

    Applicant: Thomas Moser ,  Peter Sieber ,  Thomas Schira

    Inventor： Thomas Moser ,  Peter Sieber ,  Thomas Schira

    IPC: G06F17/30

    CPC classification number: G06F17/30377 ,  Y10S707/99931 ,  Y10S707/99939 ,  Y10S707/99942 ,  Y10S707/99943

    Abstract: Some embodiments provide a system including a database, two or more data access objects, and a proxy object. In some such embodiments, each data access object has exclusive access privileges to a subset of data within the database. Further each object includes one or more of a read method that provides access to data and a write method that causes data to be stored. In such embodiments, the proxy object accesses data via data access object methods and includes a valuate method, the execution of which causes data to be passed from a data access object to the proxy object.

    Abstract translation: 一些实施例提供包括数据库，两个或更多个数据访问对象和代理对象的系统。 在一些这样的实施例中，每个数据访问对象具有对数据库内的数据子集的独占访问权限。 此外，每个对象包括提供对数据的访问的读取方法和导致数据被存储的写入方法中的一个或多个。 在这样的实施例中，代理对象通过数据访问对象方法访问数据，并且包括估价方法，其执行使数据从数据访问对象传递到代理对象。

    Peptides and process for their manufacture
    3.
    发明授权
    Peptides and process for their manufacture 失效
    肽及其制造方法

    公开(公告)号：US4159981A

    公开(公告)日：1979-07-03

    申请号：US842122

    申请日：1977-10-04

    Applicant: Werner Rittel ,  Max Brugger ,  Bruno Kamber ,  Bernhard Riniker ,  Peter Sieber ,  Hendrik M. Greven

    Inventor： Werner Rittel ,  Max Brugger ,  Bruno Kamber ,  Bernhard Riniker ,  Peter Sieber ,  Hendrik M. Greven

    IPC: A61K38/00 ,  C07K14/585 ,  C07C103/52

    CPC classification number: C07K14/585 ,  A61K38/00

    Abstract: The new hypocalcaemically active peptides of formula I ##STR1## and corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the asparagine radical, their dimers, especially those in which 2 identical peptide sequences (1-32 and 1'-32') are joined in an anti-parallel arrangement via the cysteine radicals 1,7' and 7,1' by means of a disulfide bond, and derivatives are useful as hypocalcaemic agents and are prepared by splitting off groups protecting at least one amino or one carboxyl group or oxidizing the corresponding sulfides to the disulfides or condensing together adequate peptides.

    Abstract translation: 式I的新的低活性活性肽GlyThrTyrThrGlnAspPheAsnLysPhe HisThrPheProGlnThrAlaGleVal GlyAlaProOH和其中一个或多个天冬酰胺和谷氨酸基团被天冬氨酸或谷氨酸基团和/或天冬氨酸基团代替的相应化合物被替换为 天冬酰胺基团，它们的二聚体，特别是其中2个相同的肽序列（1-32和1'-32'）通过半胱氨酸自由基1,7'和7,1'以反平行布置连接的那些，借助于 二硫键和衍生物可用作低钙血症药物，并且通过分离保护至少一个氨基或一个羧基的基团或将相应的硫化物氧化成二硫化物或将其合并在一起而制备。

    Acylpeptides
    8.
    发明授权
    Acylpeptides 失效
    酰基肽

    公开(公告)号：US4369179A

    公开(公告)日：1983-01-18

    申请号：US213299

    申请日：1980-12-05

    Applicant: Hans Rink ,  Peter Sieber ,  Bruno Kamber

    Inventor： Hans Rink ,  Peter Sieber ,  Bruno Kamber

    IPC: C07K14/575 ,  A61K38/00 ,  A61K38/04 ,  A61P43/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07K1/06 ,  C07K1/107 ,  C07K1/113 ,  C07K7/00 ,  C07K14/655 ,  A61K37/00 ,  C07C103/52

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Acylpeptides derived from somatostatin or from a derivative thereof having analogous action, in which the amino acids sequence is modified by omitting individual amino acids and/or by exchanging them for other amino acids, and in which the .epsilon.-amino group of the lysine residue in the 9-position, and optionally also the .epsilon.-amino group of the lysine residue in the 4-position and/or the N-terminal .alpha.-amino group carries the acyl radical of an optionally substituted alkanecarboxylic acid, and salts and complexes thereof can be used as antidiabetics and/or for combating gastrointestinal bleeding. They are manufactured by conventional methods of peptide chemistry.

    Abstract translation: 衍生自生长抑素或其衍生物的酰基肽具有类似作用，其中通过省略各个氨基酸修饰氨基酸序列和/或通过将其交换为其它氨基酸，并且其中赖氨酸残基的ε-氨基在 4-位和/或N-末端α-氨基的9位和任选还有赖氨酸残基的ε-氨基带有任选取代的链烷羧酸的酰基，其盐和配合物可以 用作抗糖尿病药和/或用于抵抗胃肠道出血。 它们通过肽化学的常规方法制造。

    Cyclooctapeptides
    9.
    发明授权
    Cyclooctapeptides 失效
    环肽

    公开(公告)号：US4358439A

    公开(公告)日：1982-11-09

    申请号：US216353

    申请日：1980-12-15

    Applicant: Peter Sieber ,  Bruno Kamber ,  Hans Rink

    Inventor： Peter Sieber ,  Bruno Kamber ,  Hans Rink

    IPC: C07K7/56 ,  A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P5/02 ,  C07K1/113 ,  C07K14/575 ,  C07K14/655 ,  A61K37/00 ,  C07C103/52

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Cyclic peptides of the formula ##STR1## in which trp represents L-Trp, D-Trp, or an analogous radical which carries a halogen atom in the indole nucleus, Ac.sub.A represents hydrogen, or an acyl radical Ac of a carboxylic acid present at the .epsilon.-amino group, A represents L-Phe, D-Phe, L-Phg or D-Phg, or a corresponding radical having a substituted or saturated phenyl ring, and B represents the residue of a .gamma.- or .delta.-amino-lower alkanecarboxylic acid which may carry an optionally substituted cyclic hydrocarbyl radical Ar, and also pharmacologically tolerable salts and therapeutically acceptable complexes thereof can be used as an antidiabetic in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by cyclisation of corresponding linear peptides.

    Abstract translation: 其中trp表示L-Trp，D-Trp或在吲哚核中携带卤素原子的类似基团的式（I）的环肽，AcA表示氢或羧酸的酰基Ac 存在于ε-氨基，A表示L-Phe，D-Phe，L-Phg或D-Phg或具有取代或饱和的苯环的相应基团，B表示γ或δ- 可以携带任选取代的环状烃基Ar的氨基 - 低级链烷羧酸，以及其药理学上可耐受的盐和其可治疗可接受的复合物可以以与生长抑素类似的方式用作抗糖尿病剂。 它们可以通过肽化学的常规方法获得，特别是通过相应的线性肽的环化获得。

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