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    Pharmaceutical Combination
    1.
    发明申请
    Pharmaceutical Combination 审中-公开

    公开(公告)号：US20170333369A1

    公开(公告)日：2017-11-23

    申请号：US15674407

    申请日：2017-08-10

    申请人： Gruenenthal GmbH

    发明人： Klaus SCHIENE ,  Petra BLOMS-FUNKE

    IPC分类号： A61K31/137 ,  A61K31/136 ,  A61K31/13 ,  A61K31/135 ,  A61K45/06 ,  A61K31/192

    摘要： A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one NMDA-antagonist, a pharmaceutical formulation and a dosage form comprising such a combination, and a method of treating pain, e.g. inflammatory pain or neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, with component (a) being administered either before or after component (b), and with components (a) or (b) being administered to the mammal either via the same pathway of administration or via different pathways of administration.

    Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain
    7.
    发明申请
    Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain 审中-公开
    使用1-苯基-3-二甲基氨基丙烷化合物治疗类风湿性疼痛

    公开(公告)号：US20160346228A1

    公开(公告)日：2016-12-01

    申请号：US15232419

    申请日：2016-08-09

    申请人： Gruenenthal GmbH

    发明人： Ulrich JAHNEL ,  Klaus SCHIENE

    IPC分类号： A61K31/137

    CPC分类号： A61K31/137 ,  A61K31/215

    摘要： The use of 1-phenyl-3-dimethylaminopropane compounds for the treatment of rheumatoid pain, especially rheumatoid arthritic pain, very especially preferably chronic rheumatoid arthritic pain.

    摘要翻译： 1-苯基-3-二甲基氨基丙烷化合物用于治疗类风湿性疼痛，特别是类风湿性关节炎疼痛，非常特别优选慢性类风湿性关节炎疼痛。

    Pharmaceutical Composition Comprising (1r,4r)-6'-flouro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
    8.
    发明申请
    Pharmaceutical Composition Comprising (1r,4r)-6'-flouro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative 有权
    药物组合物包含（1r，4r）-6'-氟 - N，N-二甲基-4-苯基-4'，9'-二氢-3'H-螺[环己烷-1,1'-吡喃并[ 4，b]吲哚] -4-胺和丙酸衍生物

    公开(公告)号：US20130324581A1

    公开(公告)日：2013-12-05

    申请号：US13892786

    申请日：2013-05-13

    申请人： GRUENENTHAL GMBH

    发明人： Stefanie FROSCH ,  Klaus LINZ ,  Klaus SCHIENE

    IPC分类号： A61K31/407 ,  A61K31/192

    CPC分类号： A61K31/407 ,  A61K31/192 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient, which is selected from (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient, which is a propionic acid derivative selected from the group consisting of ibuprofen, naproxen, ketoprofen, flurbiprofen, fenoprofen, fenbufen, suprofen, pirprofen, indoprofen, tiaprofenic acid, oxaprozin, ibuproxam, flunoxaprofen, alminoprofen, naproxcinod, and the physiologically acceptable salts thereof.

    摘要翻译： 本发明涉及包含第一药理活性成分的药物组合物，其选自（1r，4r）-6'-氟-N，N-二甲基-4-苯基-4'，9'-二氢-3'H - 螺[环己烷-1,1'-吡喃并[3,4，b]吲哚] -4-胺及其生理上可接受的盐，和第二药理活性成分，其是选自以下的丙酸衍生物： 布洛芬，萘普生，酮洛芬，氟比洛芬，非诺洛芬，芬布芬，依洛芬，吡柔芬，吲哚洛芬，噻吗啡酸，奥沙普秦，布洛康，氟诺洛芬，阿仑洛芬，萘普生和其生理学上可接受的盐。