公开(公告)号：US11887745B2

公开(公告)日：2024-01-30

申请号：US17960279

申请日：2022-10-05

申请人： Gregory Gaehle

发明人： Gregory Gaehle

IPC分类号： G21G1/10 ,  H05H6/00 ,  G21K5/08 ,  G21G1/00

CPC分类号： G21G1/10 ,  G21K5/08 ,  H05H6/00 ,  G21G2001/0094

摘要： Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area, resulting in improved specific activity while reducing the amount of target material used.

公开(公告)号：US20060004491A1

公开(公告)日：2006-01-05

申请号：US10914617

申请日：2004-08-09

申请人： Michael Welch ,  Lucie Tang ,  Gregory Gaehle ,  Jason Lewis

发明人： Michael Welch ,  Lucie Tang ,  Gregory Gaehle ,  Jason Lewis

IPC分类号： G05B21/00

CPC分类号： G05B19/418 ,  A61K51/1282 ,  B01D15/10 ,  B01D15/361 ,  B01D15/363 ,  G21G1/001 ,  G21G4/08 ,  G21G2001/0094

摘要： A novel method for separating an irradiated 60Cu or 61Cu or 64Cu respectively from a composition containing 60Ni or 61Ni or 64Ni respectively therein comprises dissolving the irradiated 60Cu or 61Cu or 64Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising 60Ni or 61Ni or 64Ni ions. In an aspect the eluent is further processed for 60Ni or 61Ni or 64Ni recovery and recycling to prepare future targets. In an aspect 60Cu or 61Cu or 64Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the 60Cu or 61Cu or 64Cu for further use or labeling. An enhanced process for labeling compounds with highly purified 60Cu, 61Cu or 64Cu comprises loading 60Cu, 61Cu and 64Cu elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-μL of ligand and 3N HCl solution in a reaction line to form a 60 or 61 or 64Cu labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the C18 Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and recovering 60Cu, 61Cu and 64Cu each as a separate and independent purified product.

公开(公告)号：US11495365B1

公开(公告)日：2022-11-08

申请号：US16352516

申请日：2019-03-13

申请人： Gregory Gaehle

发明人： Gregory Gaehle

IPC分类号： G21G1/10 ,  H05H6/00 ,  G21K5/08 ,  G21G1/00

摘要： Among the various aspects of the present disclosure is the provision of systems for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the system includes a target material area or target material shape that matches the proton beam strike area or proton beam strike shape, resulting in optimal thickness with less target material required.