公开(公告)号：US10793556B2

公开(公告)日：2020-10-06

申请号：US16450259

申请日：2019-06-24

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D409/06 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04

Abstract: The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20210214315A1

公开(公告)日：2021-07-15

申请号：US17188802

申请日：2021-03-01

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Florian Jakob ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10807989B2

公开(公告)日：2020-10-20

申请号：US16454489

申请日：2019-06-27

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Florian Jakob ,  Achim Kless ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Anita Wegert

IPC: C07D487/04 ,  C07K5/062 ,  C07D417/02 ,  C07D413/12 ,  C07D413/06 ,  C07D409/12 ,  C07D405/12 ,  C07D405/06 ,  C07D403/12 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06 ,  C07D235/02 ,  C07D417/12

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20210179592A1

公开(公告)日：2021-06-17

申请号：US17188743

申请日：2021-03-01

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Ingo Konetzki

IPC: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10807988B2

公开(公告)日：2020-10-20

申请号：US16450331

申请日：2019-06-24

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D409/04 ,  C07D413/02 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10738015B2

公开(公告)日：2020-08-11

申请号：US16554847

申请日：2019-08-29

Applicant: GRÜNENTHAL GMBH

Inventor： Paul Ratcliffe ,  Ingo Konetzki ,  Nikolay Sitnikov ,  Thomas Koch ,  Ruth Jostock

IPC: C07D235/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D405/14 ,  A61P25/00 ,  C07D401/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/06

Abstract: The invention relates to 1,3-diaza-spiro-[3.4]-octane derivatives, their preparation and use in medicine, particularly in various neurological disorders, including but not limited to pain, neurodegenerative disorders, neuroinflammatory disorders, neuropsychiatric disorders, substance abuse/dependence.

公开(公告)号：US20210179595A1

公开(公告)日：2021-06-17

申请号：US17188706

申请日：2021-03-01

Applicant: Grünenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D409/06 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04

Abstract: The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10793528B2

公开(公告)日：2020-10-06

申请号：US16450406

申请日：2019-06-24

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Florian Jakob ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D417/06 ,  C07D487/04 ,  C07D413/12 ,  C07D405/12

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.