公开(公告)号：US10807989B2

公开(公告)日：2020-10-20

申请号：US16454489

申请日：2019-06-27

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Florian Jakob ,  Achim Kless ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Anita Wegert

IPC: C07D487/04 ,  C07K5/062 ,  C07D417/02 ,  C07D413/12 ,  C07D413/06 ,  C07D409/12 ,  C07D405/12 ,  C07D405/06 ,  C07D403/12 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06 ,  C07D235/02 ,  C07D417/12

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10813891B2

公开(公告)日：2020-10-27

申请号：US16516856

申请日：2019-07-19

Applicant: Grünenthal GmbH

Inventor： Klaus Schiene ,  Ilona Steigerwald ,  Michel Hamon ,  Johannes Schneider ,  Silvia Reinartz ,  Ulrich Jahnel ,  Thomas Tzschentke

IPC: A61K31/137 ,  A61K9/00 ,  A61P25/04

Abstract: The use of tapentadol in the treatment of pain and/or pain chronification in a subject suffering from pain chronification and/or in the treatment of pain and inhibition of pain chronification in a subject suffering from pain and at risk of pain chronification, as well as the use of tapentadol for the treatment or inhibition of migraine.

公开(公告)号：US20210179592A1

公开(公告)日：2021-06-17

申请号：US17188743

申请日：2021-03-01

Applicant: Grünenthal GmbH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Ingo Konetzki

IPC: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.