公开(公告)号：US20180327392A1

公开(公告)日：2018-11-15

申请号：US15984919

申请日：2018-05-21

Applicant: GRÜNENTHAL GMBH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER ,  Klaus SCHIENE ,  Ingo KONETZKI

IPC: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

CPC classification number: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20200215003A1

公开(公告)日：2020-07-09

申请号：US16818275

申请日：2020-03-13

Applicant: GRÜNENTHAL GMBH

Inventor： Thomas CHRISTOPH ,  Sabine Karine Katrien INGHELBRECHT ,  Roger Carolus Augusta EMBRECHTS ,  Ulrich REINHOLD ,  Marc SCHILLER ,  Eva WULSTEN ,  Petra BLOMS-FUNKE ,  Klaus SCHIENE ,  Ulrich FEIL

IPC: A61K31/135 ,  A61K31/137 ,  A61K45/06 ,  A61K9/00

Abstract: An aqueous pharmaceutical composition adapted for parenteral administration of tapentadol or a physiologically acceptable salt thereof having a pH value of at least 5.4.

公开(公告)号：US20200009083A1

公开(公告)日：2020-01-09

申请号：US16516856

申请日：2019-07-19

Applicant: Grünenthal GmbH

Inventor： Klaus SCHIENE ,  Ilona STEIGERWALD ,  Michel HAMON ,  Johannes SCHNEIDER ,  Silvia REINARTZ ,  Ulrich JAHNEL ,  Thomas TZSCHENTKE

IPC: A61K31/137 ,  A61K9/00

Abstract: The use of tapentadol in the treatment of pain and/or pain chronification in a subject suffering from pain chronification and/or in the treatment of pain and inhibition of pain chronification in a subject suffering from pain and at risk of pain chronification, as well as the use of tapentadol for the treatment or inhibition of migraine.

公开(公告)号：US20190106430A1

公开(公告)日：2019-04-11

申请号：US16212723

申请日：2018-12-07

Applicant: GRÜNENTHAL GMBH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER ,  Klaus SCHIENE ,  Anita WEGERT

IPC: C07D487/04 ,  C07D405/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07K5/062 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D235/02

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20210179627A1

公开(公告)日：2021-06-17

申请号：US17188884

申请日：2021-03-01

Applicant: Grünenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER ,  Klaus SCHIENE ,  Anita WEGERT

IPC: C07D487/04 ,  C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07K5/062

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20190382407A1

公开(公告)日：2019-12-19

申请号：US16454489

申请日：2019-06-27

Applicant: Grünenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER ,  Klaus SCHIENE ,  Anita WEGERT

IPC: C07D487/04 ,  C07K5/062 ,  C07D417/12 ,  C07D413/12 ,  C07D413/06 ,  C07D409/12 ,  C07D405/12 ,  C07D405/06 ,  C07D403/12 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06 ,  C07D235/02

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.