公开(公告)号：US10604531B2

公开(公告)日：2020-03-31

申请号：US16097322

申请日：2017-05-01

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Steven David Knight ,  Louis Vincent Lafrance, III ,  Xinrong Tian

IPC分类号： C07D495/04

摘要： This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

公开(公告)号：US09505745B2

公开(公告)日：2016-11-29

申请号：US14787866

申请日：2014-04-25

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Charles William Blackledge, Jr. ,  Joelle Lorraine Burgess ,  Neil W. Johnson ,  Jiri Kasparec ,  Steven David Knight ,  Louis V. LaFrance, III ,  Juan I. Luengo ,  William Henry Miller ,  Kenneth Allen Newlander ,  Stuart Paul Romeril ,  Mark Schulz ,  Dai-Shi Su ,  Xinrong Tian

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D409/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/14

摘要： This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

摘要翻译： 本发明涉及式（I）的新化合物，其为Zeste同系物2（EZH2）的增效剂的抑制剂，含有它们的药物组合物，其制备方法及其在治疗癌症中的用途。

公开(公告)号：US09790212B2

公开(公告)日：2017-10-17

申请号：US15292200

申请日：2016-10-13

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Charles William Blackledge, Jr. ,  Joelle Lorraine Burgess ,  Neil W. Johnson ,  Jiri Kasparec ,  Steven David Knight ,  Louis V. LaFrance, III ,  Juan I. Luengo ,  William Henry Miller ,  Kenneth Allen Newlander ,  Stuart Paul Romeril ,  Mark Schulz ,  Dai-Shi Su ,  Xinrong Tian

IPC分类号： C07D401/12 ,  A61K31/4412 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/12 ,  C07D403/12 ,  C07D409/06

CPC分类号： C07D409/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/14

摘要： This invention relates to novel compounds according to Formula (III)(a) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), and to pharmaceutical compositions containing them.

公开(公告)号：US09556157B2

公开(公告)日：2017-01-31

申请号：US14898178

申请日：2014-07-09

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Joelle Lorraine Burgess ,  Steven David Knight

IPC分类号： C07D409/12 ,  C07D409/14 ,  A61K31/4436

CPC分类号： C07D409/14 ,  C07D409/12

摘要： This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

摘要翻译： 本发明涉及式（I）的新化合物，其为Zeste同系物2（EZH2）的增效剂的抑制剂，含有它们的药物组合物，其制备方法及其在治疗癌症中的用途。