公开(公告)号：US20240123085A1

公开(公告)日：2024-04-18

申请号：US18221211

申请日：2023-07-12

Applicant: Ginkgo Bioworks, Inc.

Inventor： James Kennon Smith

IPC: A61K48/00 ,  A61K45/06 ,  C07K14/005 ,  C12N5/0783 ,  C12N15/86

CPC classification number: A61K48/005 ,  A61K45/06 ,  C07K14/005 ,  C12N5/0636 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: The disclosure provides variant AAV capsid proteins and AAV capsids and virus vectors comprising the same. The virus vectors described herein may have increased transduction in a target cell of interest, such as a T-cell, compared to native AAV capsid sequences. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a patient in need thereof.

公开(公告)号：US20240059742A1

公开(公告)日：2024-02-22

申请号：US18372823

申请日：2023-09-26

Applicant: Ginkgo Bioworks, Inc.

Inventor： Daniel McCoy ,  Garrett E. Berry ,  James Kennon Smith

IPC: C07K14/015 ,  C07K14/47 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

CPC classification number: C07K14/015 ,  C07K14/4707 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K38/00

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the vims vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

公开(公告)号：US12091435B2

公开(公告)日：2024-09-17

申请号：US17045090

申请日：2019-04-03

Applicant: Ginkgo Bioworks, Inc.

Inventor： Daniel McCoy ,  Garrett E. Berry ,  James Kennon Smith

IPC: C12N9/22 ,  C07K14/005 ,  C07K14/015 ,  C07K14/47 ,  C12N7/00 ,  C12N15/11 ,  C12N15/86 ,  A61K38/00

CPC classification number: C07K14/015 ,  C07K14/005 ,  C07K14/4707 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K38/00 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

公开(公告)号：US12060390B2

公开(公告)日：2024-08-13

申请号：US18372823

申请日：2023-09-26

Applicant: Ginkgo Bioworks, Inc.

Inventor： Daniel McCoy ,  Garrett E. Berry ,  James Kennon Smith

IPC: C07K14/005 ,  C07K14/015 ,  C07K14/47 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K38/00

CPC classification number: C07K14/015 ,  C07K14/005 ,  C07K14/4707 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K38/00 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.