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公开(公告)号：US10472392B2
公开(公告)日：2019-11-12
申请号：US15423469
申请日：2017-02-02
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Adrian John Highton , Petr Jansa , Andrew John Keats , Linos Lazarides , Richard Mackman , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman , Greg Watt
IPC分类号： C07K5/02 , A61K38/12 , A61K39/29 , A61K38/15 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , A61K45/06 , A61K39/05 , A61K38/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：USRE47334E1
公开(公告)日：2019-04-02
申请号：US15715080
申请日：2017-09-25
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman , Jean Yves Chiva
IPC分类号： A61K38/21 , C07D498/18 , A61K38/12 , A61K45/06 , C07K5/062 , C07D487/18 , C07K5/06 , C07K5/068 , C07K5/078
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US10246486B2
公开(公告)日：2019-04-02
申请号：US15465492
申请日：2017-03-21
发明人： Caroline Aciro , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew John Keats , Linos Lazarides , Richard Mackman , Simon Neil Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman
IPC分类号： A61K38/21 , C07K5/062 , C07D487/08 , C07D498/08 , C07D498/18 , A61K38/12 , A61K39/29 , A61K45/06 , C07K5/02 , C07D471/18 , C07D498/22 , A61K38/55 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , C07K5/078 , C07K5/065 , A61K38/05 , C07K5/068 , C07K5/06 , C07K19/00 , A61K38/15 , A61K38/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US09090653B2
公开(公告)日：2015-07-28
申请号：US13913184
申请日：2013-06-07
申请人： Gilead Sciences, Inc. , Selcia Ltd.
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman
IPC分类号： A61K38/21 , C07K5/02 , C07D487/08 , C07D498/08 , C07D498/18 , C07K5/062 , A61K38/12 , A61K39/29 , A61K45/06 , C07D471/18 , C07D498/22 , A61K38/55 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , C07K5/078 , C07K5/065 , A61K38/15
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗病毒感染，特别是丙型肝炎感染。
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公开(公告)号：US20170190734A1
公开(公告)日：2017-07-06
申请号：US15423469
申请日：2017-02-02
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Adrian John Highton , Petr Jansa , Andrew John Keats , Linos Lazarides , Richard Mackman , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman , Greg Watt
CPC分类号： C07K5/0202 , A61K38/00 , A61K38/12 , A61K38/15 , A61K39/05 , A61K39/29 , A61K45/06 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US20150344521A1
公开(公告)日：2015-12-03
申请号：US14821458
申请日：2015-08-07
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew John Keats , Linos Lazarides , Richard Mackman , Simon Neil Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗病毒感染，特别是丙型肝炎感染。
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公开(公告)号：US20160220633A1
公开(公告)日：2016-08-04
申请号：US15094777
申请日：2016-04-08
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Adrian John Highton , Petr Jansa , Andrew John Keats , Linos Lazarides , Richard Mackman , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman , Greg Watt
IPC分类号： A61K38/12
CPC分类号： C07K5/0202 , A61K38/00 , A61K38/12 , A61K38/15 , A61K39/05 , A61K39/29 , A61K45/06 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US20140030221A1
公开(公告)日：2014-01-30
申请号：US13913259
申请日：2013-06-07
申请人： Selcia Ltd. , Gilead Sciences, Inc
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar karki , Adam James Schrier , Petr Jansa , Richard Mackman
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗病毒感染，特别是丙型肝炎感染。
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公开(公告)号：US20150361132A1
公开(公告)日：2015-12-17
申请号：US14719242
申请日：2015-05-21
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Adrian John Highton , Petr Jansa , Andrew John Keats , Linos Lazarides , Richard Mackman , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman , Greg Watt
CPC分类号： C07K5/0202 , A61K38/00 , A61K38/12 , A61K38/15 , A61K39/05 , A61K39/29 , A61K45/06 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US09145441B2
公开(公告)日：2015-09-29
申请号：US13913259
申请日：2013-06-07
申请人： Gilead Sciences, Inc. , Selcia Ltd.
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman , Jean Yves Chiva
IPC分类号： A61K38/21 , C07K5/062 , C07D487/18 , C07D498/18 , A61K38/12 , A61K45/06
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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