公开(公告)号：US20160199359A1

公开(公告)日：2016-07-14

申请号：US14956988

申请日：2015-12-02

申请人： Genovate Biotechnology Co., Ltd.

发明人： Jen Chen

IPC分类号： A61K31/439 ,  A61K9/70

CPC分类号： A61K31/439 ,  A61K9/7061

摘要： An antiemetic system for weekly application that contains two identical transdermal patches, a first patch and a second patch, the first patch to be administered to a subject for 3 days followed by administering the second patch to the subject for 4 days. Also disclosed is a method of treating an emesis in a subject with the above-described antiemetic system.

摘要翻译： 每周施用的止吐系统，其包含两个相同的透皮贴剂，第一贴剂和第二贴剂，待给予受试者3天的第一贴剂，然后向受试者施用第二贴剂4天。 还公开了一种用上述止吐系统治疗受试者的呕吐的方法。

公开(公告)号：US20240238272A1

公开(公告)日：2024-07-18

申请号：US18561712

申请日：2022-06-01

申请人： Genovate Biotechnology Co. Ltd.

发明人： Jen Chen ,  Chia-Chen Chu

IPC分类号： A61K31/4706 ,  A61P7/02

CPC分类号： A61K31/4706 ,  A61P7/02

摘要： A method for treating antiphospholipid syndrome by administering to a patient a pharmaceutical composition that contains S-(+)-hydroxychloroquine and a pharmaceutically acceptable excipient. The pharmaceutical composition is substantially free of R-(−)-hydroxychloroquine.

公开(公告)号：US20210369699A1

公开(公告)日：2021-12-02

申请号：US17176679

申请日：2021-02-16

申请人： Genovate Biotechnology Co. Ltd.

发明人： Jen Chen ,  Nai-tung Yao

IPC分类号： A61K31/4706

摘要： A method for treating lupus erythematosus by administering to a patient a pharmaceutical composition that contains S-hydroxychloroquine (S-HCQ) and a pharmaceutically acceptable excipient. The pharmaceutical composition is essentially free of R-hydroxychloroquine (R-HCQ). The method is effective for treating cutaneous lupus erythematosus, systemic lupus erythematosus, and patients suffering from systemic lupus erythematosus that have concurrent lupus nephritis. Administration of S-HCQ in the claimed method has fewer side effects, particularly respecting cardiotoxicity, as compared to R-HCQ and to an equimolar mixture of S-HCQ and R-HCQ.

公开(公告)号：US20210323925A1

公开(公告)日：2021-10-21

申请号：US17139135

申请日：2020-12-31

申请人： Genovate Biotechnology Co. Ltd.

发明人： Jen Chen ,  Nai-tung Yao

IPC分类号： C07D215/46

摘要： Two crystals of (S)-(+)-hydroxychloroquine sulfate. One crystal features diffraction peaks at 12.3±0.1°, 13.1±0.1°, 17.9±0.1°, 22.8±0.1°, 23.4±0.1°, 25.1±0.1°, and 26.3±0.1° as 2θ angles in a powder X-ray diffraction pattern. The other crystal features diffraction peaks at 12.8±0.1°, 14.5±0.1°, 16.7±0.1°, 17.6±0.1°, 20.2±0.1°, 21.4±0.1°, 23.8±0.1°, 25.7±0.1°, and 26.0±0.1° as 2θ angles in a powder X-ray diffraction pattern. Also disclosed are methods of preparing crystals of (S)-(+)-hydroxychloroquine sulfate.

公开(公告)号：US11578041B2

公开(公告)日：2023-02-14

申请号：US17139135

申请日：2020-12-31

申请人： Genovate Biotechnology Co. Ltd.

发明人： Jen Chen ,  Nai-tung Yao

IPC分类号： C07D215/46

摘要： Two crystals of (S)-(+)-hydroxychloroquine sulfate. One crystal features diffraction peaks at 12.3±0.1°, 13.1±0.1°, 17.9±0.1°, 22.8±0.1°, 23.4±0.1°, 25.1±0.1°, and 26.3±0.1° as 2θ angles in a powder X-ray diffraction pattern. The other crystal features diffraction peaks at 12.8±0.1°, 14.5±0.1°, 16.7±0.1°, 17.6±0.1°, 20.2±0.1°, 21.4±0.1°, 23.8±0.1°, 25.7±0.1°, and 26.0±0.1° as 2θ angles in a powder X-ray diffraction pattern. Also disclosed are methods of preparing crystals of (S)-(+)-hydroxychloroquine sulfate.