公开(公告)号：US09994505B2

公开(公告)日：2018-06-12

申请号：US14066598

申请日：2013-10-29

申请人： Genomatica, Inc.

发明人： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC分类号： C12P7/18 ,  C07C29/76

CPC分类号： C07C29/76 ,  C12P7/18 ,  C07C31/207

摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

公开(公告)号：US20240182935A1

公开(公告)日：2024-06-06

申请号：US18321585

申请日：2023-05-22

申请人： Genomatica, Inc.

发明人： Lauri H. Suominen ,  Connor J. Galleher ,  Michael Japs ,  Mark J. Burk ,  Cara Tracewell

IPC分类号： C12P13/00 ,  C12N1/02 ,  C12N1/20 ,  C12N9/88 ,  C12N9/96 ,  C12N11/16 ,  C12N15/52

CPC分类号： C12P13/001 ,  C12N1/02 ,  C12N1/20 ,  C12N9/88 ,  C12N9/96 ,  C12N11/16 ,  C12N15/52 ,  C12Y402/01001

摘要： Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

公开(公告)号：US20210130861A1

公开(公告)日：2021-05-06

申请号：US16927396

申请日：2020-07-13

申请人： Genomatica, Inc.

发明人： Lauri H. Suominen ,  Connor J. Galleher ,  Michael Japs ,  Mark J. Burk ,  Cara Tracewell

IPC分类号： C12P13/00 ,  C12N9/88 ,  C12N1/02 ,  C12N1/20 ,  C12N9/96 ,  C12N11/16 ,  C12N15/52

摘要： Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

公开(公告)号：US09556307B2

公开(公告)日：2017-01-31

申请号：US14560800

申请日：2014-12-04

申请人： MITSUBISHI CHEMICAL CORPORATION ,  GENOMATICA, INC.

发明人： Masaru Utsunomiya ,  Yusuke Izawa ,  Norikazu Konishi ,  Shinichiro Matsuzono ,  Takayuki Suzuki ,  Michael Japs ,  Mark Burk ,  Warren Clark

IPC分类号： C12P7/62 ,  C08G63/00 ,  C08G63/80 ,  C08G63/183 ,  C08G63/78 ,  C12P7/18 ,  C12N9/04 ,  C12N9/02 ,  C12N9/00

CPC分类号： C08G63/80 ,  C08G63/183 ,  C08G63/78 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/93 ,  C12P7/18 ,  C12Y101/01061 ,  C12Y102/01024 ,  C12Y102/04002 ,  C12Y602/01004 ,  Y02P20/52

摘要： The present invention aims to provide a method for producing polybutylene terephthalate (PBT) with an excellent color using biomass-derived 1,4-butanediol (BG). The invention relates to a method for producing PBT comprising a step of subjecting a diol component containing raw material 1,4-BG having a nitrogen content of 0.01 to 50 ppm by mass and a dicarboxylic acid component to esterification or ester-exchange reaction, and a polycondensation reaction step for obtaining PBT from the reactant, wherein the content of gamma butyrolactone in the raw material 1,4-BG is 1 to 100 ppm by mass.

摘要翻译： 本发明的目的在于提供使用生物质衍生的1,4-丁二醇（BG）制造具有优异颜色的聚对苯二甲酸丁二醇酯（PBT）的方法。 本发明涉及一种制备PBT的方法，包括将含有0.01〜50质量ppm的氮含量的原料1,4-BG的二醇成分和二羧酸成分进行酯化或酯交换反应的工序，以及 用于从反应物中获得PBT的缩聚反应步骤，其中原料1,4-BG中的γ-丁内酯的含量为1〜100质量ppm。

公开(公告)号：US11702682B2

公开(公告)日：2023-07-18

申请号：US16927396

申请日：2020-07-13

申请人： Genomatica, Inc.

发明人： Lauri H. Suominen ,  Connor J. Galleher ,  Michael Japs ,  Mark J. Burk ,  Cara Tracewell

IPC分类号： C12P13/00 ,  C12N9/88 ,  C12N1/02 ,  C12N1/20 ,  C12N9/96 ,  C12N11/16 ,  C12N15/52

CPC分类号： C12P13/001 ,  C12N1/02 ,  C12N1/20 ,  C12N9/88 ,  C12N9/96 ,  C12N11/16 ,  C12N15/52 ,  C12Y402/01001

摘要： Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

公开(公告)号：US10711289B2

公开(公告)日：2020-07-14

申请号：US15538448

申请日：2015-12-22

申请人： Genomatica, Inc.

发明人： Lauri H. Suominen ,  Connor J. Galleher ,  Michael Japs ,  Mark J. Burk ,  Cara Tracewell

IPC分类号： C12P13/00 ,  C12N11/16 ,  C12N9/96 ,  C12N9/88 ,  C12N1/20 ,  C12N15/52 ,  C12N1/02

摘要： Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

公开(公告)号：US10662136B2

公开(公告)日：2020-05-26

申请号：US15975630

申请日：2018-05-09

申请人： Genomatica, Inc.

发明人： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC分类号： C07C29/76 ,  C12P7/18

摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

公开(公告)号：US20140322777A1

公开(公告)日：2014-10-30

申请号：US14066598

申请日：2013-10-29

申请人： Genomatica, Inc.

发明人： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC分类号： C07C29/76 ,  C12P7/18

CPC分类号： C07C29/76 ,  C12P7/18 ,  C07C31/207

摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

摘要翻译： 从发酵液中分离1,4-丁二醇（1,4-BDO）的方法包括从含有细胞的固体部分中分离富含1,4-BDO的液体级分，从所述液体馏分中除去水，从所述 液体馏分，并纯化1,4-BDO。 生产1,4-BDO的方法包括在发酵罐中培养产生1,4-BDO的微生物足够长的时间以产生1,4-BDO。 产生1,4-BDO的微生物包括具有1,4-BDO途径的微生物，其具有编码1,4-BDO途径酶的一种或多种外源基因和/或一种或多种基因中断。 生产1,4-BDO的方法还包括分离1,4-BDO。

公开(公告)号：US11753372B2

公开(公告)日：2023-09-12

申请号：US17418060

申请日：2019-12-23

申请人： AQUAFIL S.P.A. ,  GENOMATICA INC.

发明人： Michele Cecchetto ,  Anacleto Dal Moro ,  Lauri Hannunpoika Suominen ,  Michael Japs

IPC分类号： C07D201/08

CPC分类号： C07D201/08

摘要： A new process for the production of epsilon caprolactam (CPL) from 6-aminocaproic acid (6-ACA) can be obtained either from traditional petro chemical processes or can be obtained from biochemical processes. With the proposed process, the reaction time for conversion of 6-aminocaproic acid to the Nylon 6 monomer is shorter and significant energy savings are possible which is advantageous for industrial scale production. The conversion of 6-aminocaproic acid to the Nylon 6 monomer runs at atmospheric pressure and in the final product epsilon caprolactam with no oligomers formation of significance is obtained.

公开(公告)号：US20210002194A1

公开(公告)日：2021-01-07

申请号：US16848430

申请日：2020-04-14

申请人： Genomatica, Inc.

发明人： Warren Clark ,  Michael Japs ,  Mark J. Burk

IPC分类号： C07C29/76 ,  C12P7/18

摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.