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1.发明申请公开(公告)号：US20150233803A1
公开(公告)日：2015-08-20
申请号：US14702263
申请日：2015-05-01
Applicant: General Electric Company
Inventor： Weston Blaine Griffin , Jaydeep Roy , Phillip Alexander Shoemaker , William Patrick Waters
IPC: G01N1/40
CPC classification number: A61M1/0209 , A61M1/0218 , A61M1/34 , A61M2205/3306 , A61M2205/3334 , B01D21/26 , B03D3/00
Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
Abstract translation: 一种用于处理生物材料的高通量系统，包括：托盘，其支撑功能封闭的流体路径子系统，包括：用于容纳和使所述生物材料分离成两个或更多个不同的子材料的容器; 从容器接收一个或多个子材料的一个或多个容器; 过滤装置; 导管，至少在所述容器和所述过滤装置之间运送一个或多个副材料; 和第一接合结构; 处理单元，包括：泵送装置，用于经由所述导管在至少所述容器和所述过滤装置之间移动所述副材料中的一种或多种; 对应于第一接合结构的第二接合结构; 用于至少临时将所述托盘相对于所述处理单元暂时保持在固定位置的锁定机构; 响应于一个或多个命令自动启动和停止泵送装置的控制装置。
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公开(公告)号：US10088399B2
公开(公告)日：2018-10-02
申请号：US14702263
申请日：2015-05-01
Applicant: General Electric Company
Inventor： Weston Blaine Griffin , Jaydeep Roy , Phillip Alexander Shoemaker , William Patrick Waters
Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
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Patent Agency Ranking
3.发明申请METHOD AND DEVICE FOR COLLECTION AND AMPLIFICATION OF CIRCULATING NUCLEIC ACIDS 有权用于收集和放大循环核酸的方法和装置公开(公告)号：US20150031035A1
公开(公告)日：2015-01-29
申请号：US13952173
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , John Richard Nelson , Gregory Andrew Grossmann , Ryan Charles Heller , Erin Jean Finehout , Christopher Michael Puleo , William Patrick Waters
IPC: C12Q1/68
CPC classification number: C12N15/1017 , B01L7/52 , B01L2300/0681 , C12Q1/68 , C12Q1/6844 , C12Q1/6806 , C12Q2521/501 , C12Q2531/125
Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
Abstract translation: 本文提供了从生物样品的非细胞部分收集和扩增循环核酸的方法。 从非细胞级分提取循环核酸，并进行环化以产生单链核酸环，然后通过使用随机引物的滚动循环扩增产生扩增文库，然后扩增其。 还提供了用于从生物样品中收集非细胞级分的装置。 该装置包括与过滤膜直接接触的过滤膜和干燥固体基质。
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公开(公告)号：US20170211059A1
公开(公告)日：2017-07-27
申请号：US15463943
申请日：2017-03-20
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , John Richard Nelson , Gregory Andrew GROSSMANN , Ryan Charles Heller , Erin Jean Finehout , Christopher Michael Puleo , William Patrick Waters
CPC classification number: C12N15/1017 , B01L3/5023 , B01L7/52 , B01L2300/0681 , B01L2300/0825 , C12Q1/68 , C12Q1/6844 , C12Q1/6806 , C12Q2521/501 , C12Q2531/125
Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
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公开(公告)号：US09644232B2
公开(公告)日：2017-05-09
申请号：US13952173
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , John Richard Nelson , Gregory Andrew Grossmann , Ryan Charles Heller , Erin Jean Finehout , Christopher Michael Puleo , William Patrick Waters
IPC: C12Q1/68
CPC classification number: C12N15/1017 , B01L7/52 , B01L2300/0681 , C12Q1/68 , C12Q1/6844 , C12Q1/6806 , C12Q2521/501 , C12Q2531/125
Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
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公开(公告)号：US09012060B2
公开(公告)日：2015-04-21
申请号：US13726846
申请日：2012-12-26
Applicant: General Electric Company
Inventor： John Raymond Krahn , Kristopher John Frutschy , Narayan Subramanian , William Patrick Waters , Daniel Qi Tan , William Hubert Schank
CPC classification number: H01M2/06 , H01M2/022 , H01M2/0242 , H01M2/028 , H01M2/0282 , Y10T29/49108
Abstract: In accordance with an embodiment of the invention, an assembly of tubular cell insulator casings is provided. The assembly includes a plurality of tubular cell insulator casings, wherein each cell insulator casing is open at a top end and configured to surround at least one of a plurality of electrically interconnected electrochemical cells, wherein said plurality of tubular cell insulator casings comprises a monolithic unit. The battery pack also includes a plurality of insulator plugs and a sump plate configured to support said plurality of insulator plugs.
Abstract translation: 根据本发明的实施例，提供了一种管状电池绝缘体外壳的组件。 组件包括多个管状电池绝缘体壳体，其中每个电池绝缘体外壳在顶端开口并且被配置为围绕多个电互连电化学电池中的至少一个，其中所述多个管状电池绝缘体壳体包括单片单元 。 电池组还包括多个绝缘体插头和一个配置成支撑所述多个绝缘体插头的贮槽板。
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公开(公告)号：US20140178742A1
公开(公告)日：2014-06-26
申请号：US13726846
申请日：2012-12-26
Applicant: GENERAL ELECTRIC COMPANY
Inventor： John Raymond Krahn , Kristopher John Frutschy , Narayan Subramanian , William Patrick Waters , Daniel Qi Tan , William Hubert Schank
CPC classification number: H01M2/06 , H01M2/022 , H01M2/0242 , H01M2/028 , H01M2/0282 , Y10T29/49108
Abstract: In accordance with an embodiment of the invention, an assembly of tubular cell insulator casings is provided. The assembly includes a plurality of tubular cell insulator casings, wherein each cell insulator casing is open at a top end and configured to surround at least one of a plurality of electrically interconnected electrochemical cells, wherein said plurality of tubular cell insulator casings comprises a monolithic unit. The battery pack also includes a plurality of insulator plugs and a sump plate configured to support said plurality of insulator plugs.
Abstract translation: 根据本发明的实施例，提供了一种管状电池绝缘体外壳的组件。 组件包括多个管状电池绝缘体壳体，其中每个电池绝缘体外壳在顶端开口并且被配置为围绕多个电互连电化学电池中的至少一个，其中所述多个管状电池绝缘体壳体包括单片单元 。 电池组还包括多个绝缘体插头和一个配置成支撑所述多个绝缘体插头的贮槽板。
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