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公开(公告)号：US11760744B2
公开(公告)日：2023-09-19
申请号：US16642824
申请日：2019-08-15
Applicant: Genentech, Inc.
Inventor： Aijun Lu , Sushant Malhotra , Alan G. Olivero , Cheng Shao , Yamin Zhang , Steven Do
IPC: C07D401/04 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/12 , C07D471/04
CPC classification number: C07D401/04 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/12 , C07D471/04
Abstract: Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.
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公开(公告)号：US11485745B2
公开(公告)日：2022-11-01
申请号：US16944581
申请日：2020-07-31
Applicant: Valo Health, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D491/048 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US10730889B2
公开(公告)日：2020-08-04
申请号：US15936086
申请日：2018-03-26
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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Patent Agency Ranking
公开(公告)号：US09822129B2
公开(公告)日：2017-11-21
申请号：US14382210
申请日：2013-03-01
Applicant: GENENTECH,INC. , FORMA TM, LLC , Po-Wai Yuen
Inventor： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06
CPC classification number: C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US20210171545A1
公开(公告)日：2021-06-10
申请号：US16944581
申请日：2020-07-31
Applicant: Integral Early Discovery, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D491/048 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US10696692B2
公开(公告)日：2020-06-30
申请号：US14382141
申请日：2013-03-01
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W Bair , Timm R Baumeister , Alexandre J Buckmelter , Karl H Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J Reynolds , Chase C Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zhao , Xiaozhang Zheng , Po-Wai Yuen
IPC: A61K51/00 , A61M36/14 , C07D519/00 , C07D471/04 , C07D495/04 , C07D487/04 , C07D491/048 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/551 , A61K45/06
Abstract: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US20180339998A1
公开(公告)日：2018-11-29
申请号：US15936086
申请日：2018-03-26
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , A61K45/06 , C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/438 , C07D495/04 , C07D491/048 , C07D487/04 , A61K31/501
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US20230002345A1
公开(公告)日：2023-01-05
申请号：US16642824
申请日：2019-08-15
Applicant: Genentech, Inc.
Inventor： Aijun LU , Sushant Malhotra , Alan G. Olivero , Cheng Shao , Yamin Zhang , Steven Do
IPC: C07D401/04 , C07D403/04 , C07D239/94 , C07D405/04 , C07D403/12 , C07D403/14 , C07D401/14 , C07D413/12 , C07D471/04
Abstract: Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.
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