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公开(公告)号：US20230250103A1
公开(公告)日：2023-08-10
申请号：US18299622
申请日：2023-04-12
Applicant: Genentech, Inc.
Inventor： Danial BEAUDRY , Theresa CRAVILLION , Francis GOSSELIN , Ngiap-Kie LIM , Sushant MALHOTRA , Qingping TIAN , Haiming ZHANG , Alexander GMEHLING , Alec FETTES , Stephan BACHMANN
IPC: C07D487/04 , B01J31/24
CPC classification number: C07D487/04 , B01J31/2409 , B01J31/2414 , B01J2231/40 , B01J2531/824 , C07B2200/09
Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
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公开(公告)号：US20220281893A1
公开(公告)日：2022-09-08
申请号：US17666350
申请日：2022-02-07
Applicant: Genentech, Inc.
Inventor： Lewis J. GAZZARD , Samantha Alyson GREEN , Matthew Leo LANDRY , Sushant MALHOTRA , Michael SIU , Steven DO , Yun-Xing CHENG , Limin CHENG , Jianfeng XIN , Mingtao HE
IPC: C07D498/22 , C07D519/00 , A61K31/553 , A61K45/06 , A61P35/00
Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.
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公开(公告)号：US20240383915A1
公开(公告)日：2024-11-21
申请号：US18554438
申请日：2022-04-06
Applicant: Genentech, Inc.
Inventor： Lewis J. GAZZARD , Samantha Alyson GREEN , Elizabeth H. KELLEY , Matthew Leo LANDRY , Sushant MALHOTRA , Benjamin David RAVETZ , Michael SIU , Jack Alexander TERRETT , BinQing WEI , Steven DO , Yun-Xing CHENG , Limin CHENG , Jianfeng XIN , Mingtao HE , Guosheng WU , Yinlei SUN , Cheng SHAO , Aijun LU , Yulai ZHANG
IPC: C07D498/04 , A61K31/553 , A61K45/06 , C07D519/00
Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.
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Patent Agency Ranking
公开(公告)号：US20210299110A1
公开(公告)日：2021-09-30
申请号：US17178021
申请日：2021-02-17
Applicant: Genentech, Inc.
Inventor： Timothy HEFFRON , Sushant MALHOTRA , BinQing WEI , Bryan CHAN , Lewis GAZZARD , Emanuela GANCIA , Michael LAINCHBURY , Andrew MADIN , Eileen SEWARD , Yonghan HU
IPC: A61K31/437 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/5377 , C07D471/04
Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.
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公开(公告)号：US20210079004A1
公开(公告)日：2021-03-18
申请号：US17102086
申请日：2020-11-23
Applicant: Genentech, Inc.
Inventor： Danial BEAUDRY , Theresa CRAVILLION , Francis GOSSELIN , Ngiap-Kie LIM , Sushant MALHOTRA , Qingping TIAN , Haiming ZHANG , Alexander GMEHLING , Alec FETTES , Stephan BACHMANN
IPC: C07D487/04 , B01J31/24
Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
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公开(公告)号：US20200062762A1
公开(公告)日：2020-02-27
申请号：US16460889
申请日：2019-07-02
Applicant: Genentech, Inc.
Inventor： Danial BEAUDRY , Theresa CRAVILLION , Francis GOSSELIN , Ngiap-Kie LIM , Sushant MALHOTRA , Qingping TIAN , Haiming ZHANG , Alexander GMEHLING , Alec FETTES , Stephan BACHMANN
IPC: C07D487/04 , B01J31/24
Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
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公开(公告)号：US20200000780A1
公开(公告)日：2020-01-02
申请号：US16568459
申请日：2019-09-12
Applicant: Genentech, Inc.
Inventor： Timothy HEFFRON , Sushant MALHOTRA , BinQing WEI , Bryan CHAN , Lewis GAZZARD , Emanuela GANCIA , Michael LAINCHBURY , Andrew MADIN , Eileen SEWARD , Yonghan HU
IPC: A61K31/437 , A61K31/444 , A61K31/5377 , C07D471/04 , A61K31/506 , A61K31/513
Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.
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公开(公告)号：US20180230155A1
公开(公告)日：2018-08-16
申请号：US15841828
申请日：2017-12-14
Applicant: Genentech, Inc.
Inventor： Danial BEAUDRY , Theresa CRAVILLION , Francis GOSSELIN , Ngiap-Kie LIM , Sushant MALHOTRA , Qingping TIAN , Haiming ZHANG , Alexander GMEHLING , Alec FETTES , Stephan BACHMANN
IPC: C07D487/04 , B01J31/24
CPC classification number: C07D487/04 , B01J31/2409 , B01J31/2414 , B01J2231/40 , B01J2531/824 , C07B2200/09
Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
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